Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation

Haimovici, Aladin; Brigger, Daniel; Torbett, Bruce E; Fey, Martin; Tschan, Mario (2014). Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation. Leukemia research, 38(9), pp. 1041-1047. Elsevier 10.1016/j.leukres.2014.06.010

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The PU.1 transcription factor is essential for myeloid development. We investigated if the microtubule-associated protein 1S (MAP1S) is a novel PU.1 target with a link to autophagy, a cellular recycling pathway. Comparable to PU.1, MAP1S expression was significantly repressed in primary AML blasts as compared to mature neutrophils. Accordingly, MAP1S expression was induced during neutrophil differentiation of CD34(+) progenitor and APL cells. Moreover, PU.1 bound to the MAP1S promoter and induced MAP1S expression during APL differentiation. Inhibiting MAP1S resulted in aberrant neutrophil differentiation and autophagy. Taken together, our findings implicate the PU.1-regulated MAP1S gene in neutrophil differentiation and autophagy control.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Med. Onkologie / Hämatologie (Erw.)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Med. Onkologie / Hämatologie (Erw.)

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Tumour Pathology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute for Immunology (discontinued)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Haimovici, Aladin; Brigger, Daniel; Fey, Martin and Tschan, Mario

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0145-2126

Publisher:

Elsevier

Language:

English

Submitter:

Marianne Zahn

Date Deposited:

10 Feb 2015 17:05

Last Modified:

02 Feb 2016 10:50

Publisher DOI:

10.1016/j.leukres.2014.06.010

PubMed ID:

25043887

Uncontrolled Keywords:

Acute promyelocytic leukemia, All-trans retinoic acid (ATRA), Autophagy, MAP1S, Neutrophil, PU.1

BORIS DOI:

10.7892/boris.62877

URI:

https://boris.unibe.ch/id/eprint/62877

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