Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives.

Dohan Ehrenfest, David M; Andia, Isabel; Zumstein, Matthias; Zhang, Chang-Qing; Pinto, Nelson R; Bielecki, Tomasz (2014). Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles, ligaments and tendons journal, 4(1), pp. 3-9. CIC Edizioni Internazionali S.r.l.

[img] Text
portiere.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (541kB) | Request a copy

Platelet concentrates for topical and infiltrative use - commonly termed Platetet-Rich Plasma (PRP) or Platelet-Rich Fibrin (PRF) - are used or tested as surgical adjuvants or regenerative medicine preparations in most medical fields, particularly in sports medicine and orthopaedic surgery. Even if these products offer interesting therapeutic perspectives, their clinical relevance is largely debated, as the literature on the topic is often confused and contradictory. The long history of these products was always associated with confusions, mostly related to the lack of consensual terminology, characterization and classification of the many products that were tested in the last 40 years. The current consensus is based on a simple classification system dividing the many products in 4 main families, based on their fibrin architecture and cell content: Pure Platelet-Rich Plasma (P-PRP), such as the PRGF-Endoret technique; Leukocyte- and Platelet-Rich Plasma (LPRP), such as Biomet GPS system; Pure Platelet-Rich Fibrin (P-PRF), such as Fibrinet; Leukocyte- and Platelet-Rich Fibrin (L-PRF), such as Intra-Spin L-PRF. The 4 main families of products present different biological signatures and mechanisms, and obvious differences for clinical applications. This classification serves as a basis for further investigations of the effects of these products. Perspectives of evolutions of this classification and terminology are also discussed, particularly concerning the impact of the cell content, preservation and activation on these products in sports medicine and orthopaedics.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery

UniBE Contributor:

Zumstein, Matthias

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2240-4554

Publisher:

CIC Edizioni Internazionali S.r.l.

Language:

English

Submitter:

Stefanie Zurbuchen

Date Deposited:

11 Feb 2015 13:29

Last Modified:

11 Feb 2015 13:29

PubMed ID:

24932440

Uncontrolled Keywords:

blood platelet fibrin growth factors leukocytes regenerative medicine sports medicine

BORIS DOI:

10.7892/boris.62982

URI:

https://boris.unibe.ch/id/eprint/62982

Actions (login required)

Edit item Edit item
Provide Feedback