Loss of 15-Hydroxyprostaglandin Dehydrogenase Increases Prostaglandin E2 in Pancreatic Tumors

Pham, Hung; Chen, Monica; Li, Aihua; King, Jonathan; Angst, Eliane; Dawson, David W.; Park, Jenny; Reber, Howard A.; Hines, O. Joe; Eibl, Guido (2010). Loss of 15-Hydroxyprostaglandin Dehydrogenase Increases Prostaglandin E2 in Pancreatic Tumors. Pancreas, 39(3), pp. 332-339. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/MPA.0b013e3181baecbe

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Prostaglandin E2 (PGE2) is a product of cyclooxygenase (COX) and PGE synthase (PGES) and deactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). Down-regulation of PGDH contributes to PGE2 accumulation in lung and colon cancers but has not been identified in pancreatic cancer.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Angst, Eliane

ISSN:

0885-3177

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

03 May 2014 02:50

Publisher DOI:

10.1097/MPA.0b013e3181baecbe

PubMed ID:

19820419

Web of Science ID:

000275955500007

URI:

https://boris.unibe.ch/id/eprint/63 (FactScience: 194561)

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