Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization.

Guex, A G; Frobert, A; Valentin, J; Fortunato, G; Hegemann, D; Cook, S; Carrel, Thierry; Tevaearai, Hendrik; Giraud, Marie-Noelle (2014). Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization. Acta biomaterialia, 10(7), pp. 2996-3006. Elsevier 10.1016/j.actbio.2014.01.006

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Cardiac tissue engineering approaches can deliver large numbers of cells to the damaged myocardium and have thus increasingly been considered as a possible curative treatment to counteract the high prevalence of progressive heart failure after myocardial infarction (MI). Optimal scaffold architecture and mechanical and chemical properties, as well as immune- and bio-compatibility, need to be addressed. We demonstrated that radio-frequency plasma surface functionalized electrospun poly(ɛ-caprolactone) (PCL) fibres provide a suitable matrix for bone-marrow-derived mesenchymal stem cell (MSC) cardiac implantation. Using a rat model of chronic MI, we showed that MSC-seeded plasma-coated PCL grafts stabilized cardiac function and attenuated dilatation. Significant relative decreases of 13% of the ejection fraction (EF) and 15% of the fractional shortening (FS) were observed in sham treated animals; respective decreases of 20% and 25% were measured 4 weeks after acellular patch implantation, whereas a steadied function was observed 4 weeks after MSC-patch implantation (relative decreases of 6% for both EF and FS).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Carrel, Thierry; Tevaearai, Hendrik and Giraud, Marie-Noelle

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1742-7061

Publisher:

Elsevier

Language:

English

Submitter:

Sara Baumberger

Date Deposited:

17 Feb 2015 08:57

Last Modified:

27 Oct 2015 11:28

Publisher DOI:

10.1016/j.actbio.2014.01.006

PubMed ID:

24531014

Uncontrolled Keywords:

Cardiac tissue engineering, Echocardiography, cell therapy, Electrospinning, In vivo functional evaluation, Plasma polymerization

BORIS DOI:

10.7892/boris.63194

URI:

https://boris.unibe.ch/id/eprint/63194

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