Response to LIVint-15-00100

Vinikoor, Michael J; Sinkala, Edford; Wandeler, Gilles; Chi, Benjamin H (2015). Response to LIVint-15-00100. Liver international, 35(8), p. 2060. Blackwell Munksgaard 10.1111/liv.12803

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Although AST-to-platelet ratio index (APRI) and FIB-4 have been compared with liver biopsy in patients with hepatitis C virus (HCV), hepatitis B virus (HBV), HIV/HCV co-infection, and HIV/HBV co-infection, Johannessen and Lemoine stress that they have not been validated in HIV mono-infected populations in SSA. However, this is unlikely to occur because liver biopsy does not play a role in HIV management and the procedure carries its own risks for complication. Clinicians using APRI and FIB-4 in this setting should be aware of this limitation and should interpret test results in the context of each patient's clinical scenario. This article is protected by copyright. All rights reserved.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Wandeler, Gilles

Subjects:

300 Social sciences, sociology & anthropology > 360 Social problems & social services
600 Technology > 610 Medicine & health

ISSN:

1478-3223

Publisher:

Blackwell Munksgaard

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

18 Feb 2015 09:30

Last Modified:

12 Sep 2017 06:22

Publisher DOI:

10.1111/liv.12803

PubMed ID:

25676587

Uncontrolled Keywords:

AST-to-platelet ratio index, Africa, FIB-4, HIV/AIDS, hepatitis B virus, liver disease

BORIS DOI:

10.7892/boris.63309

URI:

https://boris.unibe.ch/id/eprint/63309

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