Prevalence of type 2 diabetes is higher in peripheral artery disease than in coronary artery disease patients.

Silbernagel, Günther; Rein, Philipp; Saely, Christoph H; Engelberger, Rolf Peter; Willenberg, Torsten Andreas; Do, Dai-Do; Kucher, Nils; Baumgartner, Iris; Drexel, Heinz (2015). Prevalence of type 2 diabetes is higher in peripheral artery disease than in coronary artery disease patients. Diabetes & vascular disease research, 12(2), pp. 146-149. Sage 10.1177/1479164114560342

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Type 2 diabetes mellitus and pre-diabetes are risk factors for atherosclerosis and are highly prevalent in patients with coronary artery disease. However, the prevalence of impaired glucose metabolism in patients with peripheral artery disease is not as well elucidated. We aimed at comparing prevalence rates of type 2 diabetes mellitus and pre-diabetes, which were diagnosed according to the current American Diabetes Association criteria, among 364 patients with peripheral artery disease, 529 patients with coronary artery disease and 383 controls. The prevalence of type 2 diabetes mellitus in peripheral artery disease patients was 49.7%. It was significantly higher in these patients than in coronary artery disease patients (34.4%; p < 0.001) and controls (21.4%; p < 0.001). Adjusted for sex, age and body mass index, odds ratios for type 2 diabetes mellitus were 2.0 (95% confidence interval 1.5-2.6) comparing the peripheral artery disease group with the coronary artery disease group (p < 0.001) and 4.0 (2.8-5.8) comparing the peripheral artery disease group with controls (p < 0.001). The prevalence of pre-diabetes among non-diabetic subjects was high in all three study groups (64.5% in peripheral artery disease patients, 63.4% in coronary artery disease patients and 61.8% in controls), without significant between-group differences. In conclusion, the prevalence of type 2 diabetes mellitus is even higher in peripheral artery disease patients than in coronary artery disease patients. This observation underlines the need to consider impaired glucose regulation in the management of peripheral artery disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Silbernagel, Günther; Engelberger, Rolf Peter; Willenberg, Torsten Andreas; Do, Dai-Do; Kucher, Nils and Baumgartner, Iris

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1479-1641

Publisher:

Sage

Language:

English

Submitter:

Catherine Gut

Date Deposited:

19 Mar 2015 10:50

Last Modified:

30 Oct 2015 07:53

Publisher DOI:

10.1177/1479164114560342

PubMed ID:

25616706

Uncontrolled Keywords:

Coronary artery disease, glycated haemoglobin, oral glucose tolerance test, peripheral vascular disease, type 2 diabetes mellitus

BORIS DOI:

10.7892/boris.63361

URI:

https://boris.unibe.ch/id/eprint/63361

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