FGFR3 expression in primary invasive bladder cancers and matched lymph node metastases

Turo, Rafal; Harnden, Patricia; Thygesen, Helene; Fleischmann, Achim; Thalmann, George; Seiler, Roland; Cross, William R; Knowles, Margaret A (2015). FGFR3 expression in primary invasive bladder cancers and matched lymph node metastases. Journal of urology, 193(1), pp. 325-330. Elsevier 10.1016/j.juro.2014.06.026

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PURPOSE FGFR3 is considered a good therapeutic target for bladder cancer. However, to our knowledge it is unknown whether the FGFR3 status of primary tumors is a surrogate for related metastases, which must be targeted by FGFR targeted systemic therapies. We assessed FGFR3 protein expression in primary bladder tumors and matched nodal metastases. MATERIALS AND METHODS We examined matched primary tumor and nodal metastases from 150 patients with bladder cancer clinically staged as N0M0. Four samples per patient were incorporated into a tissue microarray and FGFR3 expression was assessed by immunohistochemistry. FGFR3 expression was tested for an association with categorical clinical data using the Fisher exact test, and with overall and recurrence-free survival by Kaplan-Meier analysis. RESULTS Duplicate spots from primary tumors and lymph node metastases were highly concordant (OR 8.6 and 16.7, respectively, each p <0.001). Overall FGFR protein expression levels did not differ between primary and metastatic lesions (p = 0.78). Up-regulated expression was recorded in 53 of 106 evaluable primary tumor spots and 56 matched metastases. Concordance of FGFR3 expression levels in 79 matched primary tumor and metastasis specimens was high (OR 8.45, p <0.001). In 15 and 12 patients expression was up-regulated in only metastasis and in only the primary tumor, respectively. Overall and recurrence-free survival was not related to FGFR3 expression. CONCLUSIONS FGFR3 expression in matched primary and metastasized bladder cancer specimens showed good but not absolute concordance. Thus, in most patients primary tumor FGFR3 status can guide the selection of FGFR targeted therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Fleischmann, Achim; Thalmann, George and Seiler, Roland

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0022-5347

Publisher:

Elsevier

Language:

English

Submitter:

Katharina Morgenegg

Date Deposited:

26 Feb 2015 14:45

Last Modified:

05 Nov 2015 10:35

Publisher DOI:

10.1016/j.juro.2014.06.026

PubMed ID:

24933362

Uncontrolled Keywords:

urinary bladder, carcinoma, neoplasm metastasis, neoplasm invasiveness, receptor, fibroblast growth factor, type 3

BORIS DOI:

10.7892/boris.63422

URI:

https://boris.unibe.ch/id/eprint/63422

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