Radiotherapy for renal-cell carcinoma

De Meerleer, Gert; Khoo, Vincent; Escudier, Bernard; Joniau, Steven; Bossi, Alberto; Ost, Piet; Briganti, Alberto; Fonteyne, Valérie; Van Vulpen, Marco; Lumen, Nicolaas; Spahn, Martin; Mareel, Marc (2014). Radiotherapy for renal-cell carcinoma. The lancet oncology, 15(4), e170-e177. Elsevier 10.1016/S1470-2045(13)70569-2

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Renal-cell carcinoma is considered to be a radioresistant tumour, but this notion might be wrong. If given in a few (even single) fractions, but at a high fraction dose, stereotactic body radiotherapy becomes increasingly important in the management of renal-cell carcinoma, both in primary settings and in treatment of oligometastatic disease. There is an established biological rationale for the radiosensitivity of renal-cell carcinoma to stereotactic body radiotherapy based on the ceramide pathway, which is activated only when a high dose per fraction is given. Apart from the direct effect of stereotactic body radiotherapy on renal-cell carcinoma, stereotactic body radiotherapy can also induce an abscopal effect. This effect, caused by immunological processes, might be enhanced when targeted drugs and stereotactic body radiotherapy are combined. Therefore, rigorous, prospective randomised trials involving a multidisciplinary scientific panel are needed urgently.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Spahn, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1474-5488

Publisher:

Elsevier

Language:

English

Submitter:

Katharina Morgenegg

Date Deposited:

26 Feb 2015 16:50

Last Modified:

05 Nov 2015 10:39

Publisher DOI:

10.1016/S1470-2045(13)70569-2

PubMed ID:

24694640

BORIS DOI:

10.7892/boris.63510

URI:

https://boris.unibe.ch/id/eprint/63510

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