Molekulare Mechanismen der Anpassungsfähigkeit der Skelettmuskulatur

Hoppeler, Hans-Heinrich; Baum, Oliver; Müller, Matthias; Lurman, Glenn (2011). Molekulare Mechanismen der Anpassungsfähigkeit der Skelettmuskulatur. Schweizerische Zeitschrift für Sportmedizin und Sporttraumatologie, 59, pp. 6-13. Bern: Schweizerische Gesellschaft für Sportmedizin SGSM

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Human skeletal muscle exhibits an outstanding phenotypic plasticity. Endurance training leads to massive increases of mitochondria and improves capillarization. Strength training increases muscle cross-sectional area mainly by increasing myofibrillar proteins. Over the last 15 years many molecular techniques have become available which have allowed for understanding of the basic adaptive mechanism behind muscle plasticity. Multiple parallel pathways increasing mainly transcriptional activities for selected muscle proteins are responsible for endurance training related muscle changes. Muscle changes associated with strength training are dominantly achieved by modifying translational mechanisms. This review intends to delineate the relevant molecular mechanism in a functional context which is responsible for the phenotypic plasticity of adult skeletal muscle tissue.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Hoppeler, Hans-Heinrich; Baum, Oliver; Müller, Matthias and Lurman, Glenn

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1022-6699

Publisher:

Schweizerische Gesellschaft für Sportmedizin SGSM

Language:

German

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:19

Last Modified:

11 Dec 2014 08:16

BORIS DOI:

10.7892/boris.6353

URI:

https://boris.unibe.ch/id/eprint/6353 (FactScience: 211298)

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