Characterization of eosinophilic esophagitis murine models using optical coherence tomography.

Alex, Aneesh; Noti, Mario; Wojno, Elia D Tait; Artis, David; Zhou, Chao (2014). Characterization of eosinophilic esophagitis murine models using optical coherence tomography. Biomedical optics express, 5(2), pp. 609-620. Optical Society of America 10.1364/BOE.5.000609

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Pre-clinical studies using murine models are critical for understanding the pathophysiological mechanisms underlying immune-mediated disorders such as Eosinophilic esophagitis (EoE). In this study, an optical coherence tomography (OCT) system capable of providing three-dimensional images with axial and transverse resolutions of 5 µm and 10 µm, respectively, was utilized to obtain esophageal images from a murine model of EoE-like disease ex vivo. Structural changes in the esophagus of wild-type (Tslpr(+/+) ) and mutant (Tslpr(-/-) ) mice with EoE-like disease were quantitatively evaluated and food impaction sites in the esophagus of diseased mice were monitored using OCT. Here, the capability of OCT as a label-free imaging tool devoid of tissue-processing artifacts to effectively characterize murine EoE-like disease models has been demonstrated.

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