Characterization of eosinophilic esophagitis murine models using optical coherence tomography.

Alex, Aneesh; Noti, Mario; Wojno, Elia D Tait; Artis, David; Zhou, Chao (2014). Characterization of eosinophilic esophagitis murine models using optical coherence tomography. Biomedical optics express, 5(2), pp. 609-620. Optical Society of America 10.1364/BOE.5.000609

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Pre-clinical studies using murine models are critical for understanding the pathophysiological mechanisms underlying immune-mediated disorders such as Eosinophilic esophagitis (EoE). In this study, an optical coherence tomography (OCT) system capable of providing three-dimensional images with axial and transverse resolutions of 5 µm and 10 µm, respectively, was utilized to obtain esophageal images from a murine model of EoE-like disease ex vivo. Structural changes in the esophagus of wild-type (Tslpr(+/+) ) and mutant (Tslpr(-/-) ) mice with EoE-like disease were quantitatively evaluated and food impaction sites in the esophagus of diseased mice were monitored using OCT. Here, the capability of OCT as a label-free imaging tool devoid of tissue-processing artifacts to effectively characterize murine EoE-like disease models has been demonstrated.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology

UniBE Contributor:

Noti, Mario

ISSN:

2156-7085

Publisher:

Optical Society of America

Language:

English

Submitter:

Doris Haefelin

Date Deposited:

23 Feb 2015 14:36

Last Modified:

05 Nov 2015 13:55

Publisher DOI:

10.1364/BOE.5.000609

PubMed ID:

24575353

Uncontrolled Keywords:

(110.4500) Optical coherence tomography (110.6880) Three-dimensional image acquisition (170.0110) Imaging systems (170.2680) Gastrointestinal (170.3880) Medical and biological imaging (170.6935) Tissue characterization

BORIS DOI:

10.7892/boris.63611

URI:

https://boris.unibe.ch/id/eprint/63611

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