Enhancing treatment effects by combining continuous theta burst stimulation with smooth pursuit training

Hopfner, Simone; Cazzoli, Dario; Müri, René Martin; Nef, Tobias; Mosimann, Urs Peter; Bohlhalter, Stephan; Vanbellingen, Tim; Nyffeler, Thomas (2015). Enhancing treatment effects by combining continuous theta burst stimulation with smooth pursuit training. Neuropsychologia, 74, pp. 145-151. Elsevier 10.1016/j.neuropsychologia.2014.10.018

[img] Text
Hopfner14_Neuropsyc.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (987kB) | Request a copy

Continuous theta burst stimulation (cTBS) represents a promising approach in the treatment of neglect syndrom. However, it is not known whether cTBS in conjunction with another technique may enhance the therapeutic effects. In the present sham-controlled study, we aimed to combine cTBS with smooth pursuit training (SPT), another method known to effectively improve neglect symptoms, and to evaluate whether this combination would result in a stronger effect than SPT alone. Eighteen patients with left spatial neglect after right-hemispheric stroke were included in the study and performed a cancellation task on a large 54.6" touchscreen monitor. A sequential application of cTBS and SPT induced a significantly greater improvement of neglect than SPT alone. After the combined application of these two methods, patients detected significantly more targets and their cancellation behaviour presented a significantly greater shift towards the contralesional hemispace. We suggest that a combined, sequential application of cTBS and SPT is a promising new approach to treat neglect.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Perzeption und Okulomotorik
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > University Psychiatric Services

UniBE Contributor:

Hopfner, Simone, Cazzoli, Dario, Müri, René Martin, Nef, Tobias, Mosimann, Urs Peter, Bohlhalter, Stephan, Vanbellingen, Tim, Nyffeler, Thomas


100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health








Valentina Rossetti

Date Deposited:

27 Feb 2015 10:27

Last Modified:

05 Dec 2022 14:41

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Cancellation task, Continuous theta burst simulation, Pursuit training, Spatial neglect





Actions (login required)

Edit item Edit item
Provide Feedback