Developmental self-construction and -configuration of functional neocortical neuronal networks.

Bauer, Roman; Zubler, Frédéric Alexis Rudolf; Pfister, Sabina; Hauri, Andreas; Pfeiffer, Michael; Muir, Dylan R; Douglas, Rodney J (2014). Developmental self-construction and -configuration of functional neocortical neuronal networks. PLoS computational biology, 10(12), e1003994. Public Library of Science 10.1371/journal.pcbi.1003994

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The prenatal development of neural circuits must provide sufficient configuration to support at least a set of core postnatal behaviors. Although knowledge of various genetic and cellular aspects of development is accumulating rapidly, there is less systematic understanding of how these various processes play together in order to construct such functional networks. Here we make some steps toward such understanding by demonstrating through detailed simulations how a competitive co-operative ('winner-take-all', WTA) network architecture can arise by development from a single precursor cell. This precursor is granted a simplified gene regulatory network that directs cell mitosis, differentiation, migration, neurite outgrowth and synaptogenesis. Once initial axonal connection patterns are established, their synaptic weights undergo homeostatic unsupervised learning that is shaped by wave-like input patterns. We demonstrate how this autonomous genetically directed developmental sequence can give rise to self-calibrated WTA networks, and compare our simulation results with biological data.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Zubler, Frédéric Alexis Rudolf

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1553-734X

Publisher:

Public Library of Science

Language:

English

Submitter:

Valentina Rossetti

Date Deposited:

26 Feb 2015 15:00

Last Modified:

26 Feb 2015 15:00

Publisher DOI:

10.1371/journal.pcbi.1003994

PubMed ID:

25474693

BORIS DOI:

10.7892/boris.63630

URI:

https://boris.unibe.ch/id/eprint/63630

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