Evidence of an association between sleep and levodopa-induced dyskinesia in an animal model of Parkinson's disease.

Galati, Salvatore; Salvadè, Agnese; Pace, Marta; Sarasso, Simone; Baracchi, Francesca; Bassetti, Claudio; Kaelin, Alain; Städler, Claudio; Stanzione, Paolo; Möller, Jens C (2015). Evidence of an association between sleep and levodopa-induced dyskinesia in an animal model of Parkinson's disease. Neurobiology of aging, 36(3), pp. 1577-1589. Elsevier 10.1016/j.neurobiolaging.2014.12.018

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Levodopa-induced dyskinesia (LID) represents a major challenge for clinicians treating patients affected by Parkinson's disease (PD). Although levodopa is the most effective treatment for PD, the remodeling effects induced by disease progression and the pharmacologic treatment itself cause a narrowing of the therapeutic window because of the development of LID. Although animal models of PD provide strong evidence that striatal plasticity underlies the development of dyskinetic movements, the pathogenesis of LID is not entirely understood. In recent years, slow homeostatic adjustment of intrinsic excitability occurring during sleep has been considered fundamental for network stabilization by gradually modifying plasticity thresholds. So far, how sleep affects on LID has not been investigated. Therefore, we measured synaptic downscaling across sleep episodes in a parkinsonian animal model showing dyskinetic movements similar to LID. Our electrophysiological, molecular, and behavioral results are consistent with an impaired synaptic homeostasis during sleep in animals showing dyskinesia. Accordingly, sleep deprivation causes an anticipation and worsening of LID supporting a link between sleep and the development of LID.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Pace, Marta; Baracchi, Francesca; Bassetti, Claudio and Kaelin, Alain

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0197-4580

Publisher:

Elsevier

Language:

English

Submitter:

Valentina Rossetti

Date Deposited:

27 Feb 2015 10:18

Last Modified:

29 Oct 2015 11:58

Publisher DOI:

10.1016/j.neurobiolaging.2014.12.018

PubMed ID:

25596726

Uncontrolled Keywords:

Levodopa-induced dyskinesia, Parkinson's disease, Sleep, Slow-wave activity, Synaptic homeostasis

BORIS DOI:

10.7892/boris.63675

URI:

https://boris.unibe.ch/id/eprint/63675

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