Differential effects of long and short carbon nanotubes on the gas-exchange region of the mouse lung

Mühlfeld, Christian; Poland, Craig A; Duffin, Rodger; Brandenberger, Christina; Murphy, Fiona A; Rothen-Rutishauser, Barbara; Gehr, Peter; Donaldson, Ken (2011). Differential effects of long and short carbon nanotubes on the gas-exchange region of the mouse lung. Nanotoxicology, 6, pp. 867-879. London: Informa Healthcare 10.3109/17435390.2011.626533

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Abstract We hypothesise that inflammatory response and morphological characteristics of lung parenchyma differ after exposure to short or long multi-walled carbon nanotubes (MWCNT). Mice were subjected to a single dose of vehicle, short or long MWCNT by pharyngeal aspiration. Bronchoalveolar lavage fluid (BALF) obtained at 24 h was analysed for inflammatory reaction and lung tissue was analysed for morphological alterations using stereology. Short MWCNT had stronger potential to induce polymorphonuclear cells whereas long MWCNT increased interleukin-6 levels in BALF. Alveolar septal fibrosis was only observed with short MWCNT. Type II pneumocyte hypertrophy was only detected with long MWCNT. There was no reduction in total alveolar surface area and no sign of type II cell hyperplasia. We observed mild inflammatory and pathological responses to short and long MWCNT in the lung parenchyma depending on the size of the applied MWCNT.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Rothen-Rutishauser, Barbara and Gehr, Peter

ISSN:

1743-5390

Publisher:

Informa Healthcare

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:19

Last Modified:

08 Jun 2016 10:24

Publisher DOI:

10.3109/17435390.2011.626533

PubMed ID:

22022959

Web of Science ID:

000310748400007

URI:

https://boris.unibe.ch/id/eprint/6376 (FactScience: 211329)

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