Minimized extracorporeal circulation does not impair cognitive brain function after coronary artery bypass grafting

Reineke, David Christian; Winkler, Bernhard Michael; König, Tobias; Meszaros, Katharina; Sodeck, Gottfried; Schönhoff, Florian; Erdös, Gabor; Czerny, Martin; Carrel, Thierry (2015). Minimized extracorporeal circulation does not impair cognitive brain function after coronary artery bypass grafting. Interactive cardiovascular and thoracic surgery, 20(1), pp. 68-73. Oxford University Press 10.1093/icvts/ivu341

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Objective evaluation of the impact of minimized extracorporeal circulation (MECC) on perioperative cognitive brain function in coronary artery bypass grafting (CABG) by electroencephalogram P300 wave event-related potentials and number connection test (NCT) as metrics of cognitive function.


Cognitive brain function was assessed in 31 patients in 2013 with a mean age of 65 years [standard deviation (SD) 10] undergoing CABG by the use of MECC with P300 auditory evoked potentials (peak latencies in milliseconds) directly prior to intervention, 7 days after and 3 months later. Number connection test, serving as method of control, was performed simultaneously in all patients.


Seven days following CABG, cognitive P300 evoked potentials were comparable with preoperative baseline values [vertex (Cz) 376 (SD 11) ms vs 378 (18) ms, P = 0.39; frontal (Fz) 377 (11) vs 379 (21) ms, P = 0.53]. Cognitive brain function at 3 months was compared with baseline values [(Cz) 376 (11) ms vs 371 (14 ms) P = 0.09; (Fz) 377 (11) ms vs 371 (15) ms, P = 0.04]. Between the first postoperative measurement and 3 months later, significant improvement was observed [(Cz) 378 (18) ms vs 371 (14) ms, P = 0.03; (Fz) 379 (21) vs 371 (15) ms, P = 0.02]. Similar clearly corresponding patterns could be obtained via the number connection test. Results could be confirmed in repeated measures analysis of variance for Cz (P = 0.05) and (Fz) results (P = 0.04).


MECC does not adversely affect cognitive brain function after CABG. Additionally, these patients experience a substantial significant cognitive improvement after 3 months, evidentiary proving that the concept of MECC ensures safety and outcome in terms of brain function.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Reineke, David Christian, Winkler, Bernhard, König, Tobias, Schönhoff, Florian, Erdoes, Gabor (A), Czerny, Martin, Carrel, Thierry


600 Technology > 610 Medicine & health




Oxford University Press




Jeannie Wurz

Date Deposited:

23 Feb 2015 16:31

Last Modified:

29 Mar 2023 23:34

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Coronary artery bypass grafting, Brain function, Minimized extracorporeal circulation circuit




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