Minimized extracorporeal circulation does not impair cognitive brain function after coronary artery bypass grafting

Reineke, David Christian; Winkler, Bernhard Michael; König, Tobias; Meszaros, Katharina; Sodeck, Gottfried; Schönhoff, Florian; Erdös, Gabor; Czerny, Martin; Carrel, Thierry (2015). Minimized extracorporeal circulation does not impair cognitive brain function after coronary artery bypass grafting. Interactive cardiovascular and thoracic surgery, 20(1), pp. 68-73. Oxford University Press 10.1093/icvts/ivu341

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OBJECTIVES Objective evaluation of the impact of minimized extracorporeal circulation (MECC) on perioperative cognitive brain function in coronary artery bypass grafting (CABG) by electroencephalogram P300 wave event-related potentials and number connection test (NCT) as metrics of cognitive function. METHODS Cognitive brain function was assessed in 31 patients in 2013 with a mean age of 65 years [standard deviation (SD) 10] undergoing CABG by the use of MECC with P300 auditory evoked potentials (peak latencies in milliseconds) directly prior to intervention, 7 days after and 3 months later. Number connection test, serving as method of control, was performed simultaneously in all patients. RESULTS Seven days following CABG, cognitive P300 evoked potentials were comparable with preoperative baseline values [vertex (Cz) 376 (SD 11) ms vs 378 (18) ms, P = 0.39; frontal (Fz) 377 (11) vs 379 (21) ms, P = 0.53]. Cognitive brain function at 3 months was compared with baseline values [(Cz) 376 (11) ms vs 371 (14 ms) P = 0.09; (Fz) 377 (11) ms vs 371 (15) ms, P = 0.04]. Between the first postoperative measurement and 3 months later, significant improvement was observed [(Cz) 378 (18) ms vs 371 (14) ms, P = 0.03; (Fz) 379 (21) vs 371 (15) ms, P = 0.02]. Similar clearly corresponding patterns could be obtained via the number connection test. Results could be confirmed in repeated measures analysis of variance for Cz (P = 0.05) and (Fz) results (P = 0.04). CONCLUSIONS MECC does not adversely affect cognitive brain function after CABG. Additionally, these patients experience a substantial significant cognitive improvement after 3 months, evidentiary proving that the concept of MECC ensures safety and outcome in terms of brain function.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Reineke, David Christian; Winkler, Bernhard Michael; König, Tobias; Schönhoff, Florian; Erdös, Gabor; Czerny, Martin and Carrel, Thierry

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1569-9293

Publisher:

Oxford University Press

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

23 Feb 2015 16:31

Last Modified:

23 Jan 2018 12:15

Publisher DOI:

10.1093/icvts/ivu341

PubMed ID:

25323401

Uncontrolled Keywords:

Coronary artery bypass grafting, Brain function, Minimized extracorporeal circulation circuit

BORIS DOI:

10.7892/boris.63826

URI:

https://boris.unibe.ch/id/eprint/63826

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