Etomidate - a review of robust evidence for its use in various clinical scenarios

Erdös, Gabor; Basciani, Reto Marco; Eberle Schnüriger, Barbara (2014). Etomidate - a review of robust evidence for its use in various clinical scenarios. Acta anaesthesiologica Scandinavica, 58(4), pp. 380-389. Wiley-Blackwell 10.1111/aas.12289

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Etomidate is an intravenous hypnotic with a favourable clinical profile in haemodynamic high-risk scenarios. Currently, there is an active debate about the clinical significance of the drug's side effects and its overall risk-benefit ratio. Etomidate-induced transient adrenocortical suppression is well documented and has been associated with increased mortality in sepsis. In surgical patients at risk of hypotensive complications, however, a review of current literature provides no robust evidence to contraindicate a single-bolus etomidate induction. Large randomised controlled trials as well as additional observational data are required to compare safety of etomidate and its alternatives.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Erdös, Gabor; Basciani, Reto Marco and Eberle Schnüriger, Barbara

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0001-5172

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

23 Feb 2015 16:48

Last Modified:

23 Jan 2018 12:15

Publisher DOI:

10.1111/aas.12289

PubMed ID:

24588359

BORIS DOI:

10.7892/boris.63828

URI:

https://boris.unibe.ch/id/eprint/63828

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