Two-dimensional and three-dimensional oxygen mapping by 3He-MRI validation in a lung phantom

Gast, Klaus Kurt; Schreiber, Wolfgang G; Herweling, Annette; Lehmann, Frank; Erdös, Gabor; Schmiedeskamp, Joerg; Kauczor, Hans-Ulrich; Eberle, Balthasar (2005). Two-dimensional and three-dimensional oxygen mapping by 3He-MRI validation in a lung phantom. European radiology, 15(9), pp. 1915-1922. Springer 10.1007/s00330-005-2778-x

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The aim of this study was to validate oxygen-sensitive 3He-MRI in noninvasive determination of the regional, two- and three-dimensional distribution of oxygen partial pressure. In a gas-filled elastic silicon ventilation bag used as a lung phantom, oxygen sensitive two- and three-dimensional 3He-MRI measurements were performed at different oxygen concentrations which had been equilibrated in a range of normal and pathologic values. The oxygen partial pressure distribution was determined from 3He-MRI using newly developed software allowing for mapping of oxygen partial pressure. The reference bulk oxygen partial pressure inside the phantom was measured by conventional respiratory gas analysis. In two-dimensional measurements, image-based and gas-analysis results correlated with r=0.98; in three-dimensional measurements the between-methods correlation coefficient was r=0.89. The signal-to-noise ratio of three-dimensional measurements was about half of that of two-dimensional measurements and became critical (below 3) in some data sets. Oxygen-sensitive 3He-MRI allows for noninvasive determination of the two- and three-dimensional distribution of oxygen partial pressure in gas-filled airspaces.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Erdös, Gabor and Eberle, Balthasar


600 Technology > 610 Medicine & health








Jeannie Wurz

Date Deposited:

23 Feb 2015 16:26

Last Modified:

23 Jan 2018 12:18

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