The longitudinal course of gross motor activity in schizophrenia - within and between episodes

Walther, Sebastian; Stegmayer, Katharina; Horn, Helge Joachim; Rampa, Luca; Razavi, Nadja; Müller, Thomas Jörg; Strik, Werner (2015). The longitudinal course of gross motor activity in schizophrenia - within and between episodes. Frontiers in psychiatry, 6(10), p. 10. Frontiers 10.3389/fpsyt.2015.00010

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Schizophrenia is associated with heterogeneous course of positive and negative symptoms. In addition, reduced motor activity as measured by wrist actigraphy has been reported. However, longitudinal studies of spontaneous motor activity are missing. We aimed to explore whether activity levels were stable within and between psychotic episodes. Furthermore, we investigated the association with the course of negative symptoms. In 45 medicated patients, we investigated motor behavior within a psychotic episode. In addition, we followed 18 medicated patients across 2 episodes. Wrist actigraphy and psychopathological ratings were applied. Within an episode symptoms changed but activity levels did not vary systematically. Activity at baseline predicted the course of negative symptoms. Between two episodes activity recordings were much more stable. Again, activity at the index episode predicted the outcome of negative symptoms. In sum, spontaneous motor activity shares trait and state characteristics, the latter are associated with negative symptom course. Actigraphy may therefore become an important ambulatory instrument to monitor negative symptoms and treatment outcome in schizophrenia.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > Other Institutions > Teaching Staff, Faculty of Medicine
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services

UniBE Contributor:

Walther, Sebastian; Stegmayer, Katharina; Horn, Helge Joachim; Rampa, Luca; Razavi, Nadja; Müller, Thomas Jörg and Strik, Werner

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

1664-0640

Publisher:

Frontiers

Language:

English

Submitter:

Sebastian Walther

Date Deposited:

03 Mar 2015 16:32

Last Modified:

26 Jun 2016 01:59

Publisher DOI:

10.3389/fpsyt.2015.00010

PubMed ID:

25698981

Uncontrolled Keywords:

PANSS, actigraphy, avolition, negative symptoms, psychosis

BORIS DOI:

10.7892/boris.63863

URI:

https://boris.unibe.ch/id/eprint/63863

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