Sudden cardiac death in individuals with normal hearts: an update

González-Melchor, Laila; Villarreal-Molina, Teresa; Iturralde-Torres, Pedro; Medeiros Domingo, Argelia (2014). Sudden cardiac death in individuals with normal hearts: an update. Archivos de cardiología de México, 84(4), pp. 293-304. Elsevier España 10.1016/j.acmx.2014.04.002

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Sudden death (SD) is a tragic event and a world-wide health problem. Every year, near 4-5 million people experience SD. SD is defined as the death occurred in 1h after the onset of symptoms in a person without previous signs of fatality. It can be named "recovered SD" when the case received medical attention, cardiac reanimation effective defibrillation or both, surviving the fatal arrhythmia. Cardiac channelopathies are a group of diseases characterized by abnormal ion channel function due to genetic mutations in ion channel genes, providing increased susceptibility to develop cardiac arrhythmias and SD. Usually the death occurs before 40 years of age and in the autopsy the heart is normal. In this review we discuss the main cardiac channelopathies involved in sudden cardiac death along with current management of cases and family members that have experienced such tragic event.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Medeiros Domingo, Argelia


600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology




Elsevier España




Argelia Medeiros Domingo

Date Deposited:

03 Mar 2015 09:35

Last Modified:

29 Oct 2015 10:26

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Sudden death, Cardiac channelopathies, Long QT syndrome, Brugada syndrome, Catecholaminergic polymorphic ventricular tachycardia, Mexico




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