Disease Caused by Mutations in NaV-β Subunit Genes

Medeiros Domingo, Argelia; Valdivia, Carmen R. (2014). Disease Caused by Mutations in NaV-β Subunit Genes. Cardiac Electrophysiology Clinics, 6(4), pp. 785-795. WB Saunders 10.1016/j.ccep.2014.08.008

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NaV-b subunits associate with the NaV-a or pore-forming subunit of the voltage-dependent sodium channel and play critical roles in channel expression, voltage dependence of the channel gating, cell adhesion, signal transduction, and channel pharmacology.
Five NaV-b subunits have been identified in humans, all of them implicated in many primary arrhythmia syndromes that cause sudden death or neurologic disorders, including long QT syndrome, Brugada syndrome, cardiac conduction disorders, idiopathic ventricular fibrillation, epilepsy, neurodegenerative diseases, and neuropsychiatric disorders.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Medeiros Domingo, Argelia

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1877-9182

Publisher:

WB Saunders

Language:

English

Submitter:

Argelia Medeiros Domingo

Date Deposited:

03 Mar 2015 09:46

Last Modified:

29 Oct 2015 10:27

Publisher DOI:

10.1016/j.ccep.2014.08.008

URI:

https://boris.unibe.ch/id/eprint/63885

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