The ADO index as a predictor of two-year mortality in general practice-based chronic obstructive pulmonary disease cohorts.

Abu Hussein, Nebal; Ter Riet, Gerben; Schoenenberger, Lucia; Bridevaux, Pierre-Olivier; Chhajed, Prashant N; Fitting, Jean-William; Geiser, Thomas; Jochmann, Anja; Joos Zellweger, Ladina; Kohler, Malcolm; Maier, Sabrina; Miedinger, David; Schafroth Török, Salome; Scherr, Andreas; Siebeling, Lara; Thurnheer, Robert; Tamm, Michael; Puhan, Milo A; Leuppi, Joerg Daniel (2014). The ADO index as a predictor of two-year mortality in general practice-based chronic obstructive pulmonary disease cohorts. Respiration, 88(3), pp. 208-214. Karger 10.1159/000363770

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BACKGROUND Existing prediction models for mortality in chronic obstructive pulmonary disease (COPD) patients have not yet been validated in primary care, which is where the majority of patients receive care. OBJECTIVES Our aim was to validate the ADO (age, dyspnoea, airflow obstruction) index as a predictor of 2-year mortality in 2 general practice-based COPD cohorts. METHODS Six hundred and forty-six patients with COPD with GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I-IV were enrolled by their general practitioners and followed for 2 years. The ADO regression equation was used to predict a 2-year risk of all-cause mortality in each patient and this risk was compared with the observed 2-year mortality. Discrimination and calibration were assessed as well as the strength of association between the 15-point ADO score and the observed 2-year all-cause mortality. RESULTS Fifty-two (8.1%) patients died during the 2-year follow-up period. Discrimination with the ADO index was excellent with an area under the curve of 0.78 [95% confidence interval (CI) 0.71-0.84]. Overall, the predicted and observed risks matched well and visual inspection revealed no important differences between them across 10 risk classes (p = 0.68). The odds ratio for death per point increase according to the ADO index was 1.50 (95% CI 1.31-1.71). CONCLUSIONS The ADO index showed excellent prediction properties in an out-of-population validation carried out in COPD patients from primary care settings.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology

UniBE Contributor:

Geiser, Thomas and Tamm, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0025-7931

Publisher:

Karger

Language:

English

Submitter:

Rahel Holderegger

Date Deposited:

10 Mar 2015 16:28

Last Modified:

29 Oct 2015 10:59

Publisher DOI:

10.1159/000363770

PubMed ID:

25115178

BORIS DOI:

10.7892/boris.64367

URI:

https://boris.unibe.ch/id/eprint/64367

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