Pharmacogenetics and forensic toxicology

Musshoff, Frank; Stamer, Ulrike M; Madea, Burkhard (2010). Pharmacogenetics and forensic toxicology. Forensic science international, 203(1-3), pp. 53-62. Shannon: Elsevier Scientific Publ. Ireland 10.1016/j.forsciint.2010.07.011

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Large inter-individual variability in drug response and toxicity, as well as in drug concentrations after application of the same dosage, can be of genetic, physiological, pathophysiological, or environmental origin. Absorption, distribution and metabolism of a drug and interactions with its target often are determined by genetic differences. Pharmacokinetic and pharmacodynamic variations can appear at the level of drug metabolizing enzymes (e.g., the cytochrome P450 system), drug transporters, drug targets or other biomarker genes. Pharmacogenetics or toxicogenetics can therefore be relevant in forensic toxicology. This review presents relevant aspects together with some examples from daily routines.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Stamer, Ulrike

ISSN:

0379-0738

Publisher:

Elsevier Scientific Publ. Ireland

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

04 Oct 2013 14:08

Last Modified:

23 Jan 2018 12:17

Publisher DOI:

10.1016/j.forsciint.2010.07.011

PubMed ID:

20828952

Web of Science ID:

000284464200007

URI:

https://boris.unibe.ch/id/eprint/645 (FactScience: 200041)

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