Extending resection and preserving function: modern concepts of glioma surgery

Schucht, Philippe; Beck, Jürgen; Seidel, Kathleen; Raabe, Andreas (2015). Extending resection and preserving function: modern concepts of glioma surgery. Swiss medical weekly, 145(w14082), w14082. EMH Schweizerischer Ärzteverlag 10.4414/smw.2015.14082

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Recent studies have demonstrated that the improved prognosis derived from resection of gliomas largely depends on the extent and quality of the resection, making maximum but safe resection the ultimate goal. Simultaneously, technical innovations and refined neurosurgical methods have rapidly improved efficacy and safety. Because gliomas derive from intrinsic brain cells, they often cannot be visually distinguished from the surrounding brain tissue during surgery. In order to appreciate the full extent of their solid compartment, various technologies have recently been introduced. However, radical resection of infiltrative glioma puts neurological function at risk, with potential detrimental consequences for patients' survival and quality of life. The allocation of various neurological functions within the brain varies in each patient and may undergo additional changes in the presence of a tumour (brain plasticity), making intra-operative localisation of eloquent areas mandatory for preservation of essential brain functions. Combining methods that visually distinguish tumour tissue and detect tissues responsible for critical functions now enables resection of tumours in brain regions that were previously considered off-limits, and benefits patients by enabling a more radical resection, while simultaneously lowering the risk of neurological deficits. Here we review recent and expected developments in microsurgery for glioma and their respective benefits.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Schucht, Philippe; Beck, Jürgen; Seidel, Kathleen and Raabe, Andreas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Nicole Söll

Date Deposited:

13 Mar 2015 16:47

Last Modified:

10 Sep 2017 08:53

Publisher DOI:

10.4414/smw.2015.14082

PubMed ID:

25651063

BORIS DOI:

10.7892/boris.64521

URI:

https://boris.unibe.ch/id/eprint/64521

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