Use of activity monitors for assessment of pruritus in an acute model of canine atopic dermatitis

Schwab-Richards, Rachel; Prost, Christine; Steffan, Jean; Seewald, Wolfgang; Nenci, Chiara; Roosje, Petra (2014). Use of activity monitors for assessment of pruritus in an acute model of canine atopic dermatitis. Veterinary dermatology, 25(5), 441-e69. Blackwell Science 10.1111/vde.12133

[img] Text
Schwab-Richards_et_al-2014-Veterinary_dermatology.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

BACKGROUND: We developed a canine model of acute atopic dermatitis to evaluate the potential of compounds to treat pruritus and skin lesions induced in Dermatophagoides farinae (Df)-sensitized dogs. HYPOTHESIS/OBJECTIVES: The aim was to investigate the effectiveness of long-term recording activity monitors to assess pruritus induced by allergen challenges. ANIMALS: Thirty-two Df-sensitized laboratory dogs. METHODS: In two blinded crossover studies, 28 Df-sensitized dogs were challenged on 3 days with a Df slurry applied to clipped abdominal skin. Dogs were treated with a positive control (prednisolone 1 mg/kg once daily for 5 days, starting 1 day before challenge) or left untreated; all were fitted with activity monitors. To confirm pruritus, a parallel study with four dogs was conducted, filming the dogs before and during challenge and assessing the film for pruritic behaviour. RESULTS: The activity of dogs treated with prednisolone was significantly lower between 00.00 and 03.00 h and between 03.00 and 06.00 h compared with untreated dogs (repeated-measures ANCOVA; P < 0.0001). To determine whether the recorded night-time activity corresponded to pruritic manifestations, we compared activity monitor and video recordings of four dogs for two periods (16.30-20.30 and 24.00-03.00 h) before and during a Df challenge. The correlation between night-time activity monitor activity and observed pruritic behaviour was highly significant (test of correlation coefficient versus zero: r = 0.57, P < 0.0001). CONCLUSIONS AND CLINICAL IMPORTANCE: Determination of night-time activity with activity monitors after allergen challenge appears to be an objective and practical way to assess pruritus in this experimental model of canine atopic dermatitis.

Item Type:

Journal Article (Original Article)


05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Dermatology

UniBE Contributor:

Roosje, Petra


500 Science > 590 Animals (Zoology)
600 Technology > 610 Medicine & health




Blackwell Science




Inga Schröder

Date Deposited:

27 Apr 2015 17:06

Last Modified:

05 Dec 2022 14:42

Publisher DOI:


PubMed ID:





Actions (login required)

Edit item Edit item
Provide Feedback