Use of activity monitors for assessment of pruritus in an acute model of canine atopic dermatitis

Schwab-Richards, Rachel; Prost, Christine; Steffan, Jean; Seewald, Wolfgang; Nenci, Chiara; Roosje, Petra (2014). Use of activity monitors for assessment of pruritus in an acute model of canine atopic dermatitis. Veterinary dermatology, 25(5), 441-e69. Blackwell Science 10.1111/vde.12133

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BACKGROUND: We developed a canine model of acute atopic dermatitis to evaluate the potential of compounds to treat pruritus and skin lesions induced in Dermatophagoides farinae (Df)-sensitized dogs. HYPOTHESIS/OBJECTIVES: The aim was to investigate the effectiveness of long-term recording activity monitors to assess pruritus induced by allergen challenges. ANIMALS: Thirty-two Df-sensitized laboratory dogs. METHODS: In two blinded crossover studies, 28 Df-sensitized dogs were challenged on 3 days with a Df slurry applied to clipped abdominal skin. Dogs were treated with a positive control (prednisolone 1 mg/kg once daily for 5 days, starting 1 day before challenge) or left untreated; all were fitted with activity monitors. To confirm pruritus, a parallel study with four dogs was conducted, filming the dogs before and during challenge and assessing the film for pruritic behaviour. RESULTS: The activity of dogs treated with prednisolone was significantly lower between 00.00 and 03.00 h and between 03.00 and 06.00 h compared with untreated dogs (repeated-measures ANCOVA; P < 0.0001). To determine whether the recorded night-time activity corresponded to pruritic manifestations, we compared activity monitor and video recordings of four dogs for two periods (16.30-20.30 and 24.00-03.00 h) before and during a Df challenge. The correlation between night-time activity monitor activity and observed pruritic behaviour was highly significant (test of correlation coefficient versus zero: r = 0.57, P < 0.0001). CONCLUSIONS AND CLINICAL IMPORTANCE: Determination of night-time activity with activity monitors after allergen challenge appears to be an objective and practical way to assess pruritus in this experimental model of canine atopic dermatitis.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Dermatology

UniBE Contributor:

Roosje, Petra

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 610 Medicine & health

ISSN:

0959-4493

Publisher:

Blackwell Science

Language:

English

Submitter:

Inga Schröder

Date Deposited:

27 Apr 2015 17:06

Last Modified:

22 Oct 2015 08:48

Publisher DOI:

10.1111/vde.12133

PubMed ID:

24889924

BORIS DOI:

10.7892/boris.64529

URI:

https://boris.unibe.ch/id/eprint/64529

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