Intracranial Aneurysm Rupture Is Predicted by Measures of Solar Activity.

Stienen, Martin N; Smoll, Nicolas R; Battaglia, Marina; Schatlo, Bawarjan; Woernle, Christoph M; Fung, Christian; Röthlisberger, Michel; Daniel, Roy Thomas; Fathi, Ali-Reza; Fandino, Javier; Hildebrandt, Gerhard; Schaller, Karl; Bijlenga, Philippe (2015). Intracranial Aneurysm Rupture Is Predicted by Measures of Solar Activity. World neurosurgery, 83(4), pp. 588-595. Elsevier 10.1016/j.wneu.2014.12.021

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OBJECTIVE The cause precipitating intracranial aneurysm rupture remains unknown in many cases. It has been observed that aneurysm ruptures are clustered in time, but the trigger mechanism remains obscure. Because solar activity has been associated with cardiovascular mortality and morbidity, we decided to study its association to aneurysm rupture in the Swiss population. METHODS Patient data were extracted from the Swiss SOS database, at time of analysis covering 918 consecutive patients with angiography-proven aneurysmal subarachnoid hemorrhage treated at 7 Swiss neurovascular centers between January 1, 2009, and December 31, 2011. The daily rupture frequency (RF) was correlated to the absolute amount and the change in various parameters of interest representing continuous measurements of solar activity (radioflux [F10.7 index], solar proton flux, solar flare occurrence, planetary K-index/planetary A-index, Space Environment Services Center [SESC] sunspot number and sunspot area) using Poisson regression analysis. RESULTS During the period of interest, there were 517 days without recorded aneurysm rupture. There were 398, 139, 27, 12, 1, and 1 days with 1, 2, 3, 4, 5, and 6 ruptures per day. Poisson regression analysis demonstrated a significant correlation of F10.7 index and RF (incidence rate ratio [IRR] = 1.006303; standard error (SE) 0.0013201; 95% confidence interval (CI) 1.003719-1.008894; P < 0.001), according to which every 1-unit increase of the F10.7 index increased the count for an aneurysm to rupture by 0.63%. A likewise statistically significant relationship of both the SESC sunspot number (IRR 1.003413; SE 0.0007913; 95% CI 1.001864-1.004965; P < 0.001) and the sunspot area (IRR 1.000419; SE 0.0000866; 95% CI 1.000249-1.000589; P < 0.001) emerged. All other variables analyzed showed no significant correlation with RF. CONCLUSIONS We found greater radioflux, SESC sunspot number, and sunspot area to be associated with an increased count of aneurysm rupture. The clinical meaningfulness of this statistical association must be interpreted carefully and future studies are warranted to rule out a type-1 error.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Fung, Christian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1878-8750

Publisher:

Elsevier

Language:

English

Submitter:

Nicole Söll

Date Deposited:

13 Mar 2015 11:33

Last Modified:

12 Nov 2015 09:00

Publisher DOI:

10.1016/j.wneu.2014.12.021

PubMed ID:

25527878

Uncontrolled Keywords:

Aneurysmal subarachnoid hemorrhage, Geomagnetic energy, Intracranial aneurysm, Rupture risk, Solar activity, Temporal clustering

BORIS DOI:

10.7892/boris.64542

URI:

https://boris.unibe.ch/id/eprint/64542

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