Bladder function in patients with dystonia undergoing deep brain stimulation

Mordasini, Livio Marco; Kessler, Thomas M.; Kiss, Bernhard; Schüpbach, Michael; Pollo, Claudio; Kaelin, Alain (2014). Bladder function in patients with dystonia undergoing deep brain stimulation. Parkinsonism & related disorders, 20(9), pp. 1015-1017. Elsevier 10.1016/j.parkreldis.2014.05.016

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INTRODUCTION Neurogenic bladder dysfunction is well described in Parkinson's disease and has a major impact on quality of live. In contrast, little is known about the extent of urinary symptoms in other movement disorders such as dystonia and about the role of the basal ganglia in bladder control.. PATIENTS AND METHODS A consecutive series of 11 patients with severe dystonia undergoing deep brain stimulation (DBS) of the globus pallidus internus was prospectively enrolled. Bladder function was assessed by the International Prostate Symptom Score and urodynamic investigation (UDI) before DBS surgery and afterwards in the conditions with and without DBS. RESULTS In UDI before DBS surgery, detrusor overactivity was found in 36% (4/11) of dystonia patients. With pallidal DBS ON, maximum flow rate significantly decreased, post-void residual significantly increased and detrusor overactivity disappeared.. CONCLUSIONS Pathological urodynamic changes can be found in a relevant percentage of dystonia patients. Pallidal DBS has a relaxing effect on detrusor function indicating a role of the basal ganglia in lower urinary tract control. Thus, a better understanding on how subcortical networks influence lower urinary tract function might open new therapeutic perspectives..

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Mordasini, Livio Marco; Kessler, Thomas M.; Kiss, Bernhard; Schüpbach, Michael; Pollo, Claudio and Kaelin, Alain

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1353-8020

Publisher:

Elsevier

Language:

English

Submitter:

Nicole Söll

Date Deposited:

16 Mar 2015 10:48

Last Modified:

12 Nov 2015 09:01

Publisher DOI:

10.1016/j.parkreldis.2014.05.016

PubMed ID:

24984838

Uncontrolled Keywords:

Bladder function, Deep brain stimulation, Dystonia, Urodynamics

BORIS DOI:

10.7892/boris.64544

URI:

https://boris.unibe.ch/id/eprint/64544

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