Combination of MRI and dynamic FET PET for initial glioma grading

Dunet, V; Maeder, P; Nicod-Lalonde, M; Lhermitte, B; Pollo, Claudio; Bloch, J; Stupp, R; Meuli, R; Prior, J O (2014). Combination of MRI and dynamic FET PET for initial glioma grading. Nuklearmedizin / Nuclear medicine, 53(4), pp. 155-161. Schattauer 10.3413/Nukmed-0650-14-03

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AIM MRI and PET with 18F-fluoro-ethyl-tyrosine (FET) have been increasingly used to evaluate patients with gliomas. Our purpose was to assess the additive value of MR spectroscopy (MRS), diffusion imaging and dynamic FET-PET for glioma grading. PATIENTS, METHODS 38 patients (42 ± 15 aged, F/M: 0.46) with untreated histologically proven brain gliomas were included. All underwent conventional MRI, MRS, diffusion sequences, and FET-PET within 3±4 weeks. Performances of tumour FET time-activity-curve, early-to-middle SUVmax ratio, choline / creatine ratio and ADC histogram distribution pattern for gliomas grading were assessed, as compared to histology. Combination of these parameters and respective odds were also evaluated. RESULTS Tumour time-activity-curve reached the best accuracy (67%) when taken alone to distinguish between low and high-grade gliomas, followed by ADC histogram analysis (65%). Combination of time-activity-curve and ADC histogram analysis improved the sensitivity from 67% to 86% and the specificity from 63-67% to 100% (p < 0.008). On multivariate logistic regression analysis, negative slope of the tumour FET time-activity-curve however remains the best predictor of high-grade glioma (odds 7.6, SE 6.8, p = 0.022). CONCLUSION Combination of dynamic FET-PET and diffusion MRI reached good performance for gliomas grading. The use of FET-PET/MR may be highly relevant in the initial assessment of primary brain tumours.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Pollo, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0029-5566

Publisher:

Schattauer

Language:

English

Submitter:

Nicole Söll

Date Deposited:

16 Mar 2015 10:46

Last Modified:

12 Nov 2015 09:01

Publisher DOI:

10.3413/Nukmed-0650-14-03

PubMed ID:

24737132

Uncontrolled Keywords:

18F-fluoro-ethyl-tyrosine, ADC histogram, MRI glioma grading

URI:

https://boris.unibe.ch/id/eprint/64545

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