Neutrophil expression of ICAM1, CXCR1, and VEGFR1 in patients with breast cancer before and after adjuvant chemotherapy

Lohri, Corinne; Schaltegger, Claudia S Hutzli; VAN DEN Broek, Maries; Wenger, Roland H; Ruegg, Curzio; Fink, Daniel; Fehr, Mathias K; Knuth, Alexander; Zweifel, Martin (2014). Neutrophil expression of ICAM1, CXCR1, and VEGFR1 in patients with breast cancer before and after adjuvant chemotherapy. Anticancer research, 34(9), pp. 4693-4699. International Inst. of Anticancer Research

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BACKGROUND Distinct populations of neutrophils have been identified based on the expression of intercellular adhesion molecule 1 (ICAM1, CD54) and chemokine receptor 1 (CXCR1, interleukin 8 receptor α). AIM We analyzed the expression of vascular endothelial growth factor receptor 1 (VEGFR1), a physiological negative regulator of angiogenesis, on distinct populations of neutrophils from the blood of patients before and after adjuvant chemotherapy for breast cancer. MATERIALS AND METHODS Neutrophil populations were distinguished as reverse transmigrated (ICAM1(high)/CXCR1(low)), naïve (ICAM1(low)/CXCR1(high)), or tissue-resident neutrophils (ICAM1(low)/CXCR1(low)), and their VEGFR1 expression quantified. RESULTS Reverse transmigrated ICAM1(high)/CXCR1(low) neutrophilic granulocytes decreased significantly after chemotherapy and these were also the cells with highest mean fluorescence intensity for VEGFR1. CONCLUSION Chemotherapy mainly reduces the number of reverse transmigrated long-lived ICAM1(high)/CXCR1(low) VEGFR1-expressing neutrophils. The decrease of antiangiogenic VEGFR1 may have a potential impact on tumour angiogenesis in patients undergoing adjuvant chemotherapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Zweifel, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0250-7005

Publisher:

International Inst. of Anticancer Research

Language:

English

Submitter:

Marianne Zahn

Date Deposited:

13 Mar 2015 11:29

Last Modified:

13 Mar 2015 11:29

PubMed ID:

25202046

Uncontrolled Keywords:

Adjuvant chemotherapy, breast cancer, chemokine receptor 1, intercellular adhesion molecule 1, neutrophilic granulocyte, tumor angiogenesis, vascular endothelial growth factor receptor 1

URI:

https://boris.unibe.ch/id/eprint/64564

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