Pharmacogenetics in palliative care

Kleine-Brueggeney, Maren; Musshoff, Frank; Stuber, Frank; Stamer, Ulrike M (2010). Pharmacogenetics in palliative care. Forensic science international, 203(1-3), pp. 63-70. Shannon: Elsevier Scientific Publ. Ireland 10.1016/j.forsciint.2010.07.003

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Response to analgesics, anticancer pharmacotherapy and pharmacotherapy of other cancer related symptoms vary broadly between individuals. Age, disease, comorbidities, concomitant medication, organ function and patients' compliance may partly explain the differences. However, the focus of ongoing research has shifted towards genomic variants of phase I and II drug metabolizing enzymes with one important goal being an individual dose adjustment according to a patient's genotype. Polymorphisms of the cytochrome P 450 2D6 influence the metabolism of many drugs including the analgesics codeine, tramadol, hydrocodone and oxycodone, as well as the metabolism of tricyclic antidepressants and the anticancer drug tamoxifen. Other candidate genes such as (opioid)-receptors, transporters and other molecules important for pharmacotherapy in pain management are discussed. Although pharmacogenetics as a diagnostic tool has the potential to improve patient therapy, study results are often equivocal and limited by small sample sizes and often by their retrospective design. Well designed studies are needed to demonstrate superiority of pharmoacogenetics to conventional dosing regimes.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Stüber, Frank and Stamer, Ulrike

ISSN:

0379-0738

Publisher:

Elsevier Scientific Publ. Ireland

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

04 Oct 2013 14:08

Last Modified:

23 Jan 2018 12:17

Publisher DOI:

10.1016/j.forsciint.2010.07.003

PubMed ID:

20709477

Web of Science ID:

000284464200008

URI:

https://boris.unibe.ch/id/eprint/646 (FactScience: 200042)

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