Le purpura thrombotique thrombocytopénique - un diagtnostic méconnu

Adler, Marcel; Kremer Hovinga, Johanna Anna; Lämmle, Bernhard (2014). Le purpura thrombotique thrombocytopénique - un diagtnostic méconnu. Revue médicale suisse, pp. 2280-2284. Médecine & Hygiène

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Thrombotic thrombocytopenic purpura (TTP) is a disease characterized by mechanical anemia with fragmentation of red blood cells and thrombocytopenia by consumption. The physiopathology has been extensively studied and a severe deficiency of ADAMTS13, proteolytic enzyme of von Willebrand factor (vWF), has been shown to be responsible for its manifestation. We stress the importance of visual blood smear examination when clinical and hematological features of TTP are present, as it seems to be under-diagnosed, especially in infants and young adults. Superpositions with diarrhea-associated hemolytic uremic syndrome (D+ HUS) and atypical HUS (aHUS) are controversely discussed. Henceforth this article proposes a non-exhaustive review of current diagnostic, therapeutic and prognostic features of these diseases.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Adler, Marcel; Kremer Hovinga, Johanna Anna and Lämmle, Bernhard

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0025-6749

Publisher:

Médecine & Hygiène

Language:

French

Submitter:

Verena Zwahlen

Date Deposited:

17 Mar 2015 14:59

Last Modified:

11 Oct 2017 12:13

BORIS DOI:

10.7892/boris.64632

URI:

https://boris.unibe.ch/id/eprint/64632

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