Retinal layer measurements after successful macula-off retinal detachment repair using optical coherence tomography

Menke, Marcel; Kowal, Horst Jens; Dufour, Pascal André; Wolf-Schnurrbusch, Ute; Ceklic, Lala; Framme, Carsten Karl Josef; Wolf, Sebastian (2014). Retinal layer measurements after successful macula-off retinal detachment repair using optical coherence tomography. Investigative ophthalmology & visual science, 55(10), pp. 6575-6579. Association for Research in Vision and Ophthalmology 10.1167/iovs.14-14412

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PURPOSE Optical coherence tomography (OCT) was used to analyze the thickness of various retinal layers of patients following successful macula-off retinal detachment (RD) repair. METHODS Optical coherence tomography scans of patients after successful macula-off RD repair were reanalyzed with a subsegmentation algorithm to measure various retinal layers. Regression analysis was performed to correlate time after surgery with changes in layer thickness. In addition, patients were divided in two groups. Group 1 had a follow-up period after surgery of up to 7 weeks (range, 21-49 days). In group 2, the follow-up period was >8 weeks (range, 60-438 days). Findings were compared to a group of age-matched healthy controls. RESULTS Correlation analysis showed a significant positive correlation between inner nuclear-outer plexiform layer (INL-OPL) thickness and time after surgery (P=0.0212; r2=0.1551). Similar results were found for the ellipsoid zone-retinal pigment epithelium complex (EZ-RPE) thickness (P=0.005; r2=0.2215). Ganglion cell-inner plexiform layer thickness (GCL-IPL) was negatively correlated with time after surgery (P=0.0064; r2=0.2101). For group comparison, the retinal nerve fiber layer in both groups was thicker compared to controls. The GCL-IPL showed significant thinning in group 2. The outer nuclear layer was significantly thinner in groups 1 and 2 compared to controls. The EZ-RPE complex was significantly thinner in groups 1 and 2 compared to controls. In addition, values in group 1 were significantly thinner than in group 2. CONCLUSIONS Optical coherence tomography retinal layer thickness measurements after successful macular-off RD repair revealed time-dependent thickness changes. Inner nuclear-outer plexiform layer thickness and EZ-RPE thickness was positively correlated with time after surgery. Ganglion cell-inner plexiform layer thickness was negatively correlated with time after surgery.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Menke, Marcel; Kowal, Horst Jens; Dufour, Pascal André; Wolf-Schnurrbusch, Ute; Framme, Carsten Karl Josef and Wolf, Sebastian

Subjects:

600 Technology > 610 Medicine & health
500 Science

ISSN:

0146-0404

Publisher:

Association for Research in Vision and Ophthalmology

Language:

English

Submitter:

Sebastian Wolf

Date Deposited:

16 Mar 2015 12:17

Last Modified:

05 Nov 2015 09:36

Publisher DOI:

10.1167/iovs.14-14412

PubMed ID:

25190655

Uncontrolled Keywords:

OCT, retinal detachment, image analysis, subsegmentation

URI:

https://boris.unibe.ch/id/eprint/64680

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