Menke, Marcel; Kowal, Horst Jens; Dufour, Pascal André; Wolf-Schnurrbusch, Ute; Ceklic, Lala; Framme, Carsten Karl Josef; Wolf, Sebastian (2014). Retinal layer measurements after successful macula-off retinal detachment repair using optical coherence tomography. Investigative ophthalmology & visual science, 55(10), pp. 6575-6579. Association for Research in Vision and Ophthalmology 10.1167/iovs.14-14412
Full text not available from this repository. (Request a copy)PURPOSE
Optical coherence tomography (OCT) was used to analyze the thickness of various retinal layers of patients following successful macula-off retinal detachment (RD) repair.
METHODS
Optical coherence tomography scans of patients after successful macula-off RD repair were reanalyzed with a subsegmentation algorithm to measure various retinal layers. Regression analysis was performed to correlate time after surgery with changes in layer thickness. In addition, patients were divided in two groups. Group 1 had a follow-up period after surgery of up to 7 weeks (range, 21-49 days). In group 2, the follow-up period was >8 weeks (range, 60-438 days). Findings were compared to a group of age-matched healthy controls.
RESULTS
Correlation analysis showed a significant positive correlation between inner nuclear-outer plexiform layer (INL-OPL) thickness and time after surgery (P=0.0212; r2=0.1551). Similar results were found for the ellipsoid zone-retinal pigment epithelium complex (EZ-RPE) thickness (P=0.005; r2=0.2215). Ganglion cell-inner plexiform layer thickness (GCL-IPL) was negatively correlated with time after surgery (P=0.0064; r2=0.2101). For group comparison, the retinal nerve fiber layer in both groups was thicker compared to controls. The GCL-IPL showed significant thinning in group 2. The outer nuclear layer was significantly thinner in groups 1 and 2 compared to controls. The EZ-RPE complex was significantly thinner in groups 1 and 2 compared to controls. In addition, values in group 1 were significantly thinner than in group 2.
CONCLUSIONS
Optical coherence tomography retinal layer thickness measurements after successful macular-off RD repair revealed time-dependent thickness changes. Inner nuclear-outer plexiform layer thickness and EZ-RPE thickness was positively correlated with time after surgery. Ganglion cell-inner plexiform layer thickness was negatively correlated with time after surgery.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Menke, Marcel, Kowal, Horst Jens, Dufour, Pascal André, Wolf-Schnurrbusch, Ute, Framme, Carsten Karl Josef, Wolf, Sebastian (B) |
Subjects: |
600 Technology > 610 Medicine & health 500 Science |
ISSN: |
0146-0404 |
Publisher: |
Association for Research in Vision and Ophthalmology |
Language: |
English |
Submitter: |
Sebastian Wolf |
Date Deposited: |
16 Mar 2015 12:17 |
Last Modified: |
05 Dec 2022 14:42 |
Publisher DOI: |
10.1167/iovs.14-14412 |
PubMed ID: |
25190655 |
Uncontrolled Keywords: |
OCT, retinal detachment, image analysis, subsegmentation |
URI: |
https://boris.unibe.ch/id/eprint/64680 |
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