Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria.

Schippling, S; Balk, Lj; Costello, F; Albrecht, P; Balcer, L; Calabresi, Pa; Frederiksen, Jl; Frohman, E; Green, Aj; Klistorner, A; Outteryck, O; Paul, F; Plant, Gt; Traber, G; Vermersch, P; Villoslada, P; Wolf, Sebastian; Petzold, A (2015). Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria. Multiple sclerosis journal, 21(2), pp. 163-170. Sage 10.1177/1352458514538110

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BACKGROUND Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research. OBJECTIVE An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials. METHODS A prospective multi-centre (n = 13) study. Peripapillary ring scan QC rating of an OCT training set (n = 50) was followed by a test set (n = 50). Inter-rater agreement was calculated using kappa statistics. Results were discussed at a round table after the assessment had taken place. RESULTS The inter-rater QC agreement was substantial (kappa = 0.7). Disagreement was found highest for judging signal strength (kappa = 0.40). Future steps to resolve these issues were discussed. CONCLUSION Substantial agreement for QC assessment was achieved with aid of the OSCAR-IB criteria. The task force has developed a website for free online training and QC certification. The criteria may prove useful for future research and trials in MS using OCT as a secondary outcome measure in a multi-centre setting.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Wolf, Sebastian

Subjects:

600 Technology > 610 Medicine & health
500 Science

ISSN:

1352-4585

Publisher:

Sage

Language:

English

Submitter:

Sebastian Wolf

Date Deposited:

19 Mar 2015 09:51

Last Modified:

19 Mar 2015 09:51

Publisher DOI:

10.1177/1352458514538110

PubMed ID:

24948688

Uncontrolled Keywords:

Atrophy, multiple sclerosis, outcome measurement, progressive

URI:

https://boris.unibe.ch/id/eprint/64683

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