The ARCH Projects: design and rationale (IAASSG 001).

Yan, Tristan D; Tian, David H; LeMaire, Scott A; Misfeld, Martin; Elefteriades, John A; Chen, Edward P; Hughes, G Chad; Kazui, Teruhisa; Griepp, Randall B; Kouchoukos, Nicholas T; Bannon, Paul G; Underwood, Malcolm J; Mohr, Friedrich-Wilhelm; Oo, Aung; Sundt, Thoralf M; Bavaria, Joseph E; Di Bartolomeo, Roberto; Di Eusanio, Marco; Roselli, Eric E; Beyersdorf, Friedhelm; ... (2014). The ARCH Projects: design and rationale (IAASSG 001). European journal of cardio-thoracic surgery, 45(1), pp. 10-16. Oxford University Press 10.1093/ejcts/ezt520

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OBJECTIVE A number of factors limit the effectiveness of current aortic arch studies in assessing optimal neuroprotection strategies, including insufficient patient numbers, heterogenous definitions of clinical variables, multiple technical strategies, inadequate reporting of surgical outcomes and a lack of collaborative effort. We have formed an international coalition of centres to provide more robust investigations into this topic. METHODS High-volume aortic arch centres were identified from the literature and contacted for recruitment. A Research Steering Committee of expert arch surgeons was convened to oversee the direction of the research. RESULTS The International Aortic Arch Surgery Study Group has been formed by 41 arch surgeons from 10 countries to better evaluate patient outcomes after aortic arch surgery. Several projects, including the establishment of a multi-institutional retrospective database, randomized controlled trials and a prospectively collected database, are currently underway. CONCLUSIONS Such a collaborative effort will herald a turning point in the surgical management of aortic arch pathologies and will provide better powered analyses to assess the impact of varying surgical techniques on mortality and morbidity, identify predictors for neurological and operative risk, formulate and validate risk predictor models and review long-term survival outcomes and quality-of-life after arch surgery.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Carrel, Thierry


600 Technology > 610 Medicine & health




Oxford University Press




Sara Baumberger

Date Deposited:

17 Mar 2015 16:39

Last Modified:

23 Oct 2019 15:45

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Aortic arch surgery, Cerebral protection, Database




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