Sex- and gender-related risk factor burden in patients with premature acute coronary syndrome

Choi, Jin; Daskalopoulou, Stella Styliani; Thanassoulis, George; Karp, Igor; Pelletier, Roxanne; Behlouli, Hassan; Pilote, Louise; Rodondi, Nicolas (2014). Sex- and gender-related risk factor burden in patients with premature acute coronary syndrome. Canadian journal of cardiology, 30(1), pp. 109-117. Canadian Cardiology Publications 10.1016/j.cjca.2013.07.674

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BACKGROUND Few contemporary data exist on traditional (TRF) and non-TRF (NTRF) burden in patients with premature acute coronary syndrome (ACS). METHODS Prevalence of TRFs and NTRFs were measured in 1015 young (55 years old or younger) ACS patients recruited from 26 centres in Canada, the United States, and Switzerland. Risk factors were compared across sex and family history categories, and against a sample of the general Canadian population based on the 2000-2001 Canadian Community Health Survey. The 10- and 30-year risks of cardiovascular disease (CVD) were estimated using Framingham Risk Scores. RESULTS Risk factors were more prevalent in premature ACS patients compared with the general population. Young women with a family history of coronary artery disease showed the greatest risk factor burden including TRFs of hypertension (67%), dyslipidemia (67%), obesity (53%), smoking (42%), and diabetes (33%), and NTRFs of anxiety (55%), low household income (44%), and depression (37%). The estimated median 10-year risk of CVD was 7% (interquartile range [IQR], 3%-9%) in women and 13% (IQR, 7%-17%) in men, whereas the 30-year risk of CVD was 36% (IQR, 22%-49%) in women and 44% (IQR, 31%-57%) in men. CONCLUSIONS Patients with premature ACS, especially women with a positive family history, are characterized by a very high risk factor burden that is poorly captured by 10-year risk estimates but better captured by 30-year estimates. Consideration of NTRFs and use of 30-year risk estimates might better estimate risk in young individuals and improve the prevention of premature ACS.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Rodondi, Nicolas


600 Technology > 610 Medicine & health




Canadian Cardiology Publications




Patricia Rajaonina

Date Deposited:

18 Mar 2015 12:28

Last Modified:

09 Nov 2015 10:53

Publisher DOI:


PubMed ID:





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