Subclinical hypothyroidism: summary of evidence in 2014

Baumgartner, Christine; Blum, Manuel R; Rodondi, Nicolas (2014). Subclinical hypothyroidism: summary of evidence in 2014. Swiss medical weekly, 144, w14058. EMH Schweizerischer Ärzteverlag 10.4414/smw.2014.14058

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Subclinical hypothyroidism, which is defined as elevated thyroid-stimulating hormone (TSH) levels with free thyroxine concentrations within the reference range, is a common disorder that increases with age and affects up to 18% of the elderly, with a higher prevalence in women compared to men. Prospective data have shown an increased risk of coronary heart disease events, heart failure, and cardiovascular mortality among affected adults. Conflicting results have been found on the association between subclinical hypothyroidism and cognitive impairment, depression and the risk of fractures. Management strategies including screening and treatment of subclinical hypothyroidism are still controversial, while the ongoing European randomised controlled trial "TRUST" targets to solve these uncertainties. This narrative review aims to assess current evidence on the clinical aspects, as well as screening and treatment recommendations in adults with subclinical hypothyroidism.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Baumgartner, Christine and Rodondi, Nicolas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Patricia Rajaonina

Date Deposited:

18 Mar 2015 14:14

Last Modified:

18 Mar 2015 14:14

Publisher DOI:

10.4414/smw.2014.14058

PubMed ID:

25536449

BORIS DOI:

10.7892/boris.65200

URI:

https://boris.unibe.ch/id/eprint/65200

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