Vitamin D status among children and adolescents on anticonvulsant drugs in southern Switzerland.

Ramelli, Vera; Ramelli, Gian Paolo; Lava, Sebastiano; Siegenthaler, Giordano M; Cantù, Marco; Bianchetti, Mario Giovanni; Ceschi, Alessandro (2014). Vitamin D status among children and adolescents on anticonvulsant drugs in southern Switzerland. Swiss medical weekly, 144, w13996. EMH Schweizerischer Ärzteverlag 10.4414/smw.2014.13996

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INTRODUCTION It is recognised that vitamin D status is often inadequate (<50 nmol/l) in epileptic children, mainly because some anticonvulsant drugs induce the enzymes responsible for its metabolism. The purpose of the present study was to address vitamin D status among children and adolescents treated with anticonvulsant drugs and control subjects who reside in southern Switzerland, a high solar radiation region. METHODS Between January and May 2013, total serum 25-hydroxyvitamin D was assessed by liquid chromatography-tandem mass spectrometry in 58 children and adolescents with epilepsy and 29 controls residing in southern Switzerland. Dark-skinned individuals, females wearing dress styles covering practically the whole body and subjects with body mass index ≥85th percentile for age and sex were excluded. RESULTS Concentration of serum 25-hydroxyvitamin D was similar in epilepsy patients (48 [37-62] nmol/l; median and interquartile range) and controls (53 [47-64] nmol/l). An inadequate serum 25-hydroxyvitamin D concentration was common both among patients (55%) and control subjects (34%). Serum 25-hydroxyvitamin D was significantly lower among patients treated with anticonvulsant drugs that induce the metabolism of vitamin D (30 [21-51] nmol/l) than among the remaining patients (51 [40-65] nmol/l) and controls. CONCLUSIONS The present study indicates a relevant tendency towards inadequate vitamin D status among children with and without anticonvulsant drug management who reside in southern Switzerland. This tendency is more prominent in patients treated with anticonvulsant drugs that induce the metabolism of 25-hydroxyvitamin D.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Nephrology

UniBE Contributor:

Lava, Sebastiano and Bianchetti, Mario Giovanni

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

André Schaller

Date Deposited:

19 Mar 2015 11:22

Last Modified:

19 Mar 2015 11:22

Publisher DOI:

10.4414/smw.2014.13996

PubMed ID:

25118788

BORIS DOI:

10.7892/boris.65285

URI:

https://boris.unibe.ch/id/eprint/65285

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