Taste acceptability of pulverized brand-name and generic drugs containing amlodipine or candesartan.

Uestuener, Peter; Ferrarini, Alessandra; Santi, Maristella; Mardegan, Chiara; Bianchetti, Mario Giovanni; Simonetti, Giacomo; Milani, Gregorio P; Lava, Sebastiano (2014). Taste acceptability of pulverized brand-name and generic drugs containing amlodipine or candesartan. International journal of pharmaceutics, 468(1-2), pp. 196-198. Elsevier 10.1016/j.ijpharm.2014.04.035

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Trials with pulverized brand-name antihypertensive drugs suggest that, from the perspective of taste acceptability, crushed candesartan, chlortalidon, hydrochlorothiazide, lercanidipine and lisinopril should be preferred to pulverized amlodipine, atenolol, bisoprolol, enalapril, irbesartan, losartan, ramipril, telmisartan and valsartan. Brand-name antihypertensive drugs and the corresponding generic medicines have never been compared with respect to their taste acceptability. We therefore investigated among healthy health care workers the taste acceptability of a pulverized 1 mg-test dose of the brand-name and two generics containing either the dihydropyridine calcium-channel blocker amlodipine (Norvasc(®), Amlodipin-Mepha(®) and Amlodipin Pfizer(®)) or the angiotensin receptor antagonist candesartan (Atacand(®), Cansartan-Mepha(®) and Pemzek(®)). For this purpose, a smiley-face scale depicting four degrees of pleasure was used. Between November and December 2013, the taste test was performed among 19 nurses (15 female and 4 male subjects) and 12 physicians (5 female and 7 male subjects) aged between 25 and 49 years. Pulverized brand-names and generics containing either amlodipine or candesartan did not differ with respect to their taste acceptability.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Bianchetti, Mario Giovanni; Simonetti, Giacomo and Lava, Sebastiano

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0378-5173

Publisher:

Elsevier

Language:

English

Submitter:

André Schaller

Date Deposited:

19 Mar 2015 11:29

Last Modified:

29 Oct 2015 10:17

Publisher DOI:

10.1016/j.ijpharm.2014.04.035

PubMed ID:

24746411

Uncontrolled Keywords:

Amlodipine (PubChem CID: 2162), Angiotensin receptor antagonists, Calcium-channel blockers, Candesartan cilexetil (PubChem CID: 2540), Hypertension, Medication adherence Taste perception

BORIS DOI:

10.7892/boris.65287

URI:

https://boris.unibe.ch/id/eprint/65287

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