Factors affecting cognitive outcome in early pediatric stroke

Studer, Martina; Boltshauser, Eugen; Capone-Mori, Andrea; Datta, Alexandre; Fluss, Joel; Mercati, Danielle; Hackenberg, Annette; Keller, Elmar; Maier, Oliver; Marcoz, Jean-Pierre; Ramelli, Gian-Paolo; Poloni, Claudia; Schmid, Regula; Schmitt-Mechelke, Thomas; Wehrli, Edith Angela; Heinks, Theda; Steinlin, Maja (2014). Factors affecting cognitive outcome in early pediatric stroke. Neurology, 82(9), pp. 784-792. Lippincott Williams & Wilkins 10.1212/WNL.0000000000000162

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OBJECTIVE We examined cognitive performance in children after stroke to study the influence of age at stroke, seizures, lesion characteristics, neurologic impairment (NI), and functional outcome on cognitive outcome. METHODS This was a prospectively designed study conducted in 99 children who sustained an arterial ischemic stroke (AIS) between the age of 1 month and 16 years. All children underwent cognitive and neurologic follow-up examination sessions 2 years after the insult. Cognitive development was assessed with age-appropriate instruments. RESULTS Although mean cognitive performance was in the lower normative range, we found poorer results in subtests measuring visuoconstructive skills, short-term memory, and processing speed. Risk factors for negative cognitive outcome were young age at stroke, seizures, combined lesion location (cortical and subcortical), as well as marked NI. CONCLUSIONS We recommend that all children with a history of AIS undergo regularly scheduled neuropsychological assessment to ensure implementation of appropriate interventions and environmental adjustments as early as possible.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Studer, Martina; Wehrli, Edith Angela and Steinlin, Maja


600 Technology > 610 Medicine & health




Lippincott Williams & Wilkins




André Schaller

Date Deposited:

18 Mar 2015 15:59

Last Modified:

18 Mar 2015 15:59

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