Current aspects and future prospects of total anorectal reconstruction - a critical and comprehensive review of the literature

Inglin, Roman; Eberli, Daniel; Brügger, Lukas; Sulser, Tullio; Williams, Norman S.; Candinas, Daniel (2015). Current aspects and future prospects of total anorectal reconstruction - a critical and comprehensive review of the literature. International journal of colorectal disease, 30(3), pp. 293-302. Springer 10.1007/s00384-014-2065-x

[img] Text
art%3A10.1007%2Fs00384-014-2065-x.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (239kB) | Request a copy

PURPOSE: Many rectal cancer patients undergo abdominoperineal excision worldwide every year. Various procedures to restore perineal (pseudo-) continence, referred to as total anorectal reconstruction, have been proposed. The best technique, however, has not yet been defined. In this study, the different reconstruction techniques with regard to morbidity, functional outcome and quality of life were analysed. Technical and timing issues (i.e. whether the definitive procedure should be performed synchronously or be delayed), oncological safety, economical aspects as well as possible future improvements are further discussed. METHODS: A MEDLINE and EMBASE search was conducted to identify the pertinent multilingual literature between 1989 and 2013. All publications meeting the defined inclusion/exclusion criteria were eligible for analysis. RESULTS: Dynamic graciloplasty, artificial bowel sphincter, circular smooth muscle cuff or gluteoplasty result in median resting and squeezing neo-anal pressures that equate to the measurements found in incontinent patients. However, quality of life was generally stated to be good by patients who had undergone the procedures, despite imperfect continence, faecal evacuation problems and a considerable associated morbidity. Many patients developed an alternative perception for the urge to defecate that decisively improved functional outcome. Theoretical calculations suggested cost-effectiveness of total anorectal reconstruction compared well to life with a permanent colostomy. CONCLUSIONS: Many patients would be highly motivated to have their abdominal replaced by a functional perineal colostomy. Given the considerable morbidity and questionable functional outcome of current reconstruction technique improvements are required. Tissue engineering might be an option to design an anatomically and physiologically matured, and customised continence organ.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Inglin, Roman; Brügger, Lukas and Candinas, Daniel


600 Technology > 610 Medicine & health








Lilian Karin Smith-Wirth

Date Deposited:

27 Mar 2015 12:18

Last Modified:

10 Nov 2016 22:38

Publisher DOI:


PubMed ID:





Actions (login required)

Edit item Edit item
Provide Feedback