Vehreschild, J J; Böhme, A; Cornely, O A; Kahl, C; Karthaus, M; Kreuzer, K-A; Maschmeyer, G; Mousset, S; Ossendorf, V; Penack, O; Vehreschild, M J G T; Bohlius, J (2014). Prophylaxis of infectious complications with colony-stimulating factors in adult cancer patients undergoing chemotherapy-evidence-based guidelines from the Infectious Diseases Working Party AGIHO of the German Society for Haematology and Medical Oncology (DGHO). Annals of oncology, 25(9), pp. 1709-1718. Oxford University Press 10.1093/annonc/mdu035
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BACKGROUND
Current evidence on myelopoietic growth factors is difficult to overview for the practicing haematologist/oncologist. International guidelines are sometimes conflicting, exclude certain patient groups, or cannot directly be applied to the German health system. This guideline by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO) gives evidence-based recommendations for the use of G-CSF, pegylated G-CSF, and biosimilars to prevent infectious complications in cancer patients undergoing chemotherapy, including those with haematological malignancies.
METHODS
We systematically searched and evaluated current evidence. An expert panel discussed the results and recommendations. We then compared our recommendations to current international guidelines.
RESULTS
We summarised the data from eligible studies in evidence tables, developed recommendations for different entities and risk groups.
CONCLUSION
Comprehensive literature search and expert panel consensus confirmed many key recommendations given by international guidelines. Evidence for growth factors during acute myeloid leukaemia induction chemotherapy and pegfilgrastim use in haematological malignancies was rated lower compared with other guidelines.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Bohlius, Julia Friederike |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0923-7534 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Doris Kopp Heim |
Date Deposited: |
01 Apr 2015 11:10 |
Last Modified: |
02 Mar 2023 23:26 |
Publisher DOI: |
10.1093/annonc/mdu035 |
PubMed ID: |
24631945 |
Uncontrolled Keywords: |
G-CSF, cancer, evidence-based guideline, febrile neutropenia, infection, supportive care |
BORIS DOI: |
10.7892/boris.65611 |
URI: |
https://boris.unibe.ch/id/eprint/65611 |
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