IgA-Nephropathie und Purpura Schönlein-Henoch - ein breites Spektrum

Mani, Laila-Yasmin; Huynh-Do, Uyen; Vogt, Bruno; Ackermann, Daniel (2015). IgA-Nephropathie und Purpura Schönlein-Henoch - ein breites Spektrum. Therapeutische Umschau, 72(3), pp. 157-160. Huber 10.1024/0040-5930/a000659

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IgA nephropathy is the most common glomerulonephritis in Europe. The disease has been discovered in 1968 in Paris by Jean Berger at the Necker-Children's Hospital. Diagnosis is made by kidney biopsy and requires the presence of mesangial deposits of IgA. This form of glomerulonephritis can be seen in children and adults. In childhood, it most frequently presents within the context of Schoenlein-Henoch purpura. In adulthood, the most common form is limited to the kidney. Schoenlein-Henoch purpura can be seen in adults and manifests as a very aggressive vasculitis, usually in the context of a specific drug intake. The underlying pathophysiological concept today is an insufficient glycosylation of the IgA1 hinge region triggering the formation of autoantibodies against this site. Therapeutic options for the disease are limited. Important is optimal blood pressure control. Selected patients will profit from steroid therapy.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Nephrologie / Hypertonie

UniBE Contributor:

Mani, Laila-Yasmin; Huynh-Do, Uyen; Vogt, Bruno and Ackermann, Daniel

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0040-5930

Publisher:

Huber

Language:

German

Submitter:

Daniel Ackermann

Date Deposited:

02 Apr 2015 07:57

Last Modified:

10 Oct 2019 15:38

Publisher DOI:

10.1024/0040-5930/a000659

PubMed ID:

25722308

BORIS DOI:

10.7892/boris.65678

URI:

https://boris.unibe.ch/id/eprint/65678

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