Effect of pulsatility on the mathematical modeling of rotary blood pumps

Pirbodaghi, Tohid; Weber, Alberto; Carrel, Thierry; Vandenberghe, Stijn (2011). Effect of pulsatility on the mathematical modeling of rotary blood pumps. Artificial organs, 35(8), pp. 825-832. Malden, Mass.: Wiley-Blackwell 10.1111/j.1525-1594.2003.07198.x

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In this study, the effect of time derivatives of flow rate and rotational speed was investigated on the mathematical modeling of a rotary blood pump (RBP). The basic model estimates the pressure head of the pump as a dependent variable using measured flow and speed as predictive variables. Performance of the model was evaluated by adding time derivative terms for flow and speed. First, to create a realistic working condition, the Levitronix CentriMag RBP was implanted in a sheep. All parameters from the model were physically measured and digitally acquired over a wide range of conditions, including pulsatile speed. Second, a statistical analysis of the different variables (flow, speed, and their time derivatives) based on multiple regression analysis was performed to determine the significant variables for pressure head estimation. Finally, different mathematical models were used to show the effect of time derivative terms on the performance of the models. In order to evaluate how well the estimated pressure head using different models fits the measured pressure head, root mean square error and correlation coefficient were used. The results indicate that inclusion of time derivatives of flow and speed can improve model accuracy, but only minimally.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE)

UniBE Contributor:

Pirbodaghi, Tohid; Weber, Alberto; Carrel, Thierry and Vandenberghe, Stijn

ISSN:

0160-564X

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:20

Last Modified:

14 Mar 2014 10:46

Publisher DOI:

10.1111/j.1525-1594.2003.07198.x

PubMed ID:

21793862

Web of Science ID:

000187343400007

URI:

https://boris.unibe.ch/id/eprint/6604 (FactScience: 211600)

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