Laboratory recommendations for scoring deep molecular responses following treatment for chronic myeloid leukemia.

Cross, N C P; White, H E; Colomer, D; Ehrencrona, H; Foroni, L; Gottardi, E; Lange, T; Lion, T; Machova Polakova, K; Dulucq, S; Martinelli, G; Oppliger Leibundgut, Elisabeth; Pallisgaard, N; Barbany, G; Sacha, T; Talmaci, R; Izzo, B; Saglio, G; Pane, F; Müller, M C; ... (2015). Laboratory recommendations for scoring deep molecular responses following treatment for chronic myeloid leukemia. Leukemia, 29(5), pp. 999-1003. Nature Publishing Group 10.1038/leu.2015.29

[img]
Preview
Text
EO_2014_leu201529a_Laboratory recommendations.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (261kB) | Preview

Treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors has advanced to a stage where many patients achieve very low or undetectable levels of disease. Remarkably, some of these patients remain in sustained remission when treatment is withdrawn, suggesting that they may be at least operationally cured of their disease. Accurate definition of deep molecular responses (MRs) is therefore increasingly important for optimal patient management and comparison of independent data sets. We previously published proposals for broad standardized definitions of MR at different levels of sensitivity. Here we present detailed laboratory recommendations, developed as part of the European Treatment and Outcome Study for CML (EUTOS), to enable testing laboratories to score MR in a reproducible manner for CML patients expressing the most common BCR-ABL1 variants.Leukemia advance online publication, 27 February 2015; doi:10.1038/leu.2015.29.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene)

UniBE Contributor:

Oppliger Leibundgut, Elisabeth

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0887-6924

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Verena Zwahlen

Date Deposited:

09 Apr 2015 09:45

Last Modified:

09 Sep 2017 07:43

Publisher DOI:

10.1038/leu.2015.29

PubMed ID:

25652737

BORIS DOI:

10.7892/boris.66106

URI:

https://boris.unibe.ch/id/eprint/66106

Actions (login required)

Edit item Edit item
Provide Feedback