Chickenpox is not always benign: postvaricella purpura fulminans requires prompt and aggressive treatment

Fluri, Simon; Kaczala, Gregor W; Leibundgut, Kurt; Alberio, Lorenzo (2010). Chickenpox is not always benign: postvaricella purpura fulminans requires prompt and aggressive treatment. Pediatric emergency care, 26(12), pp. 932-4. Baltimore, Md.: Williams & Wilkins 10.1097/PEC.0b013e3181fe91cd

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We present 2 patients, who were admitted owing to rapidly progressing purpuric lesions due to postvaricella purpura fulminans, a coagulopathy leading to life- or limb-threatening thrombosis caused by a severe transient autoimmune protein S deficiency. Laboratory results were being consistent with disseminated intravascular coagulation secondary to protein S deficiency; treatment with fresh frozen plasma, intravenous immunoglobulins, and prednisone was started. In our experience, a prompt therapy may limit the course and the extent of the disease. We present a review of the topic with supporting literature for the therapeutic options. Therefore, we should be reminded that purpura fulminans is a rare but severe complication of chickenpox, which demands quick action.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Fluri, Simon, Kaczala, Gregor Wladyslaw Eusebius, Leibundgut, Kurt, Alberio, Lorenzo




Williams & Wilkins




Anette van Dorland

Date Deposited:

04 Oct 2013 14:08

Last Modified:

05 Dec 2022 14:00

Publisher DOI:


PubMed ID:


Web of Science ID:


URI: (FactScience: 200333)

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