Chickenpox is not always benign: postvaricella purpura fulminans requires prompt and aggressive treatment

Fluri, Simon; Kaczala, Gregor W; Leibundgut, Kurt; Alberio, Lorenzo (2010). Chickenpox is not always benign: postvaricella purpura fulminans requires prompt and aggressive treatment. Pediatric emergency care, 26(12), pp. 932-4. Baltimore, Md.: Williams & Wilkins 10.1097/PEC.0b013e3181fe91cd

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We present 2 patients, who were admitted owing to rapidly progressing purpuric lesions due to postvaricella purpura fulminans, a coagulopathy leading to life- or limb-threatening thrombosis caused by a severe transient autoimmune protein S deficiency. Laboratory results were being consistent with disseminated intravascular coagulation secondary to protein S deficiency; treatment with fresh frozen plasma, intravenous immunoglobulins, and prednisone was started. In our experience, a prompt therapy may limit the course and the extent of the disease. We present a review of the topic with supporting literature for the therapeutic options. Therefore, we should be reminded that purpura fulminans is a rare but severe complication of chickenpox, which demands quick action.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Fluri, Simon; Kaczala, Gregor Wladyslaw Eusebius; Leibundgut, Kurt and Alberio, Lorenzo

ISSN:

0749-5161

Publisher:

Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:08

Last Modified:

06 Dec 2013 13:20

Publisher DOI:

10.1097/PEC.0b013e3181fe91cd

PubMed ID:

21131808

Web of Science ID:

000284943800014

URI:

https://boris.unibe.ch/id/eprint/662 (FactScience: 200333)

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