New ischaemic brain lesions in cervical artery dissection stratified to antiplatelets or anticoagulants.

Gensicke, H; Ahlhelm, F; Jung, Simon; von Hessling, A; Traenka, C; Goeggel Simonetti, B; Peters, N; Bonati, L H; Fischer, Urs; Broeg-Morvay, Anne; Seiffge, D J; Gralla, Jan; Stippich, C; Baumgartner, R W; Lyrer, P A; Arnold, Marcel; Engelter, S T (2015). New ischaemic brain lesions in cervical artery dissection stratified to antiplatelets or anticoagulants. European journal of neurology, 22(5), pp. 859-865. Blackwell Science 10.1111/ene.12682

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To determine the frequency of new ischaemic or hemorrhagic brain lesions on early follow-up magnetic resonance imaging (MRI) in patients with cervical artery dissection (CAD) and to investigate the relationship with antithrombotic treatment.


This prospective observational study included consecutive CAD patients with ischaemic or non-ischaemic symptoms within the preceding 4 weeks. All patients had baseline brain MRI scans at the time of CAD diagnosis and follow-up MRI scans within 30 days thereafter. Ischaemic lesions were detected by diffusion-weighted imaging (DWI), intracerebral bleeds (ICBs) by paramagnetic-susceptible sequences. Outcome measures were any new DWI lesions or ICBs on follow-up MRI scans. Kaplan-Meier statistics and calculated odds ratios with 95% confidence intervals were used for lesion occurrence, baseline characteristics and type of antithrombotic treatment (antiplatelet versus anticoagulant).


Sixty-eight of 74 (92%) CAD patients were eligible for analysis. Median (interquartile range) time interval between baseline and follow-up MRI scans was 5 (3-10) days. New DWI lesions occurred in 17 (25%) patients with a cumulative 30-day incidence of 41.3% (standard error 8.6%). Occurrence of new DWI lesions was associated with stroke or transient ischaemic attack at presentation [7.86 (2.01-30.93)], occlusion of the dissected vessel [4.09 (1.24-13.55)] and presence of DWI lesions on baseline MRI [6.67 (1.70-26.13)]. The type of antithrombotic treatment had no impact either on occurrence of new DWI lesions [1.00 (0.32-3.15)] or on functional 6-month outcome [1.27 (0.41-3.94)]. No new ICBs were observed.


New ischaemic brain lesions occurred in a quarter of CAD patients, independently of the type of antithrombotic treatment. MRI findings could potentially serve as surrogate outcomes in pilot treatment trials.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Jung, Simon, Fischer, Urs Martin, Broeg-Morvay, Anne, Gralla, Jan, Arnold, Marcel


600 Technology > 610 Medicine & health




Blackwell Science




Martin Zbinden

Date Deposited:

07 Apr 2015 16:01

Last Modified:

02 Mar 2023 23:26

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

DWI lesions, anticoagulation, aspirin, cervical artery dissection, stroke, treatment




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