A role for GRK2 in myocardial ischemic injury: indicators of a potential future therapy and diagnostic

Brinks, Henriette; Das, Amrit; Koch, Walter J (2011). A role for GRK2 in myocardial ischemic injury: indicators of a potential future therapy and diagnostic. Future cardiology, 7(4), pp. 547-56. London: Future Medicine Ltd 10.2217/fca.11.36

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Morbidity and mortality of myocardial infarction remains significant with resulting left ventricular function presenting as a major determinant of clinical outcome. Protecting the myocardium against ischemia reperfusion injury has become a major therapeutic goal and the identification of key signaling pathways has paved the way for various interventions, but until now with disappointing results. This article describes the recently discovered new role of G-protein-coupled receptor kinase-2 (GRK2), which is known to critically influence the development and progression of heart failure, in acute myocardial injury. This article focuses on potential applications of the GRK2 peptide inhibitor βARKct in ischemic myocardial injury, the use of GRK2 as a biomarker in acute myocardial infarction and discusses the challenges of translating GRK2 inhibition as a cardioprotective strategy to a possible future clinical application.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Most, Henriette

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1744-8298

Publisher:

Future Medicine Ltd

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:20

Last Modified:

17 Dec 2014 07:34

Publisher DOI:

10.2217/fca.11.36

PubMed ID:

21797749

URI:

https://boris.unibe.ch/id/eprint/6628 (FactScience: 211626)

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