Eisele, Philipp; Griebe, Martin; Szabo, Kristina; Wolf, Marc E; Alonso, Angelika; Engelhardt, Britta; Hennerici, Michael G; Gass, Achim (2015). Investigation of leptomeningeal enhancement in MS: A postcontrast FLAIR MRI study. Neurology, 84(8), pp. 770-775. Lippincott Williams & Wilkins 10.1212/WNL.0000000000001286
![[img]](https://boris.unibe.ch/style/images/fileicons/text.png) |
Text
Neurology-2015-Eisele-770-5.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (659kB) |
OBJECTIVE
To investigate possible leptomeningeal contrast enhancement using postcontrast fluid-attenuated inversion recovery (FLAIR) MRI as an additional marker of inflammation in patients with multiple sclerosis (MS).
METHODS
A cohort of 112 patients (73 women) with clinically definitive MS or a clinically isolated syndrome suggestive of CNS demyelination were included. A pathologic control group of 5 stroke patients was also examined. MRI was performed on a 3T system including FLAIR, T2-weighted, T1-weighted-contrast injection, followed by T1-weighted and FLAIR.
RESULTS
Of the 112 patients, 39 had an acute relapse at the time of MRI. In total, 96 contrast-enhancing lesions were identified on postcontrast T1-weighted images. The pathologic control group demonstrated the sensitivity of postcontrast FLAIR images demonstrating leptomeningeal enhancement in all cases. In contrast, only 1 out of 112 examined patients with MS showed a single area of abnormal leptomeningeal contrast enhancement.
CONCLUSIONS
In contrast to intraparenchymal blood-brain barrier (BBB) dysfunction that is frequently seen in patients with MS, BBB dysfunction of leptomeningeal vessels is usually not detectable in patients with early MS.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute |
UniBE Contributor: |
Engelhardt, Britta |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0028-3878 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Ursula Zingg-Zünd |
Date Deposited: |
07 Apr 2015 13:35 |
Last Modified: |
05 Dec 2022 14:44 |
Publisher DOI: |
10.1212/WNL.0000000000001286 |
PubMed ID: |
25616480 |
BORIS DOI: |
10.7892/boris.66316 |
URI: |
https://boris.unibe.ch/id/eprint/66316 |
Actions (login required)
 |
Edit item |