Nonthymoma-associated exfoliative dermatitis in 18 cats.

Linek, Monika; Rüfenacht, Silvia; Brachelente, Chiara; von Tscharner, Claudia; Favrot, Claude; Wilhelm, Sylvia; Nett, Claudia; Mueller, Ralf S; Mayer, Ursula; Welle, Monika Maria (2015). Nonthymoma-associated exfoliative dermatitis in 18 cats. Veterinary dermatology, 26(1), pp. 40-45. Blackwell Science 10.1111/vde.12169

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BACKGROUND Exfoliative dermatitis has been described in cats as a paraneoplastic skin disease associated with thymoma. There are anecdotal reports of cases without thymoma, with various suspected aetiologies. HYPOTHESIS/OBJECTIVES To identify common features, underlying causes, response to therapy and outcome of nonthymoma-associated exfoliative dermatitis in cats. METHODS Retrospective analysis was carried out of cases presented to dermatology referral centres or cases submitted for histopathological examination. Detailed historical and clinical data were obtained and evaluated statistically. Histopathology was reviewed in a blinded fashion by three dermatopathologists, and PCR for herpesvirus was performed. RESULTS Eighteen cats fulfilled all inclusion criteria. There was no sex, age or breed predisposition. All cats presented with severe generalized (77%) or multifocal exfoliation (23%); 12 cats were severely depressed. In all cats, thymoma was excluded radiographically and feline leukaemia virus tests were negative. Additional imaging procedures in 14 cats and postmortem examination in two cats did not detect neoplasia. Histopathology revealed interface dermatitis, mural interface folliculitis and sebaceous adenitis indistinguishable from findings in thymoma-associated cases. PCR for herpes DNA was negative. No aetiology was identified. Treatment in 12 cases consisted of immunosuppressive doses of corticosteroids and/or ciclosporin; one responded to antibiotics, one to shampoo, two went into spontaneous remission, and two did not receive any therapy and were euthanized. CONCLUSIONS AND CLINICAL IMPORTANCE Nonthymoma-associated exfoliative dermatitis in cats is clinically and histopathologically indistinguishable from thymoma-associated cases. Most cases benefit from immunosuppressive therapy; therefore, an immunopathological response to an undefined trigger is suspected.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Rüfenacht, Silvia; Brachelente, Chiara; von Tscharner, Claudia and Welle, Monika Maria

Subjects:

600 Technology > 630 Agriculture

ISSN:

0959-4493

Publisher:

Blackwell Science

Language:

English

Submitter:

Barbara Gautschi-Steffen

Date Deposited:

31 Mar 2015 13:29

Last Modified:

15 Oct 2015 10:52

Publisher DOI:

10.1111/vde.12169

PubMed ID:

25367344

BORIS DOI:

10.7892/boris.66333

URI:

https://boris.unibe.ch/id/eprint/66333

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