Associations between mood, anxiety or substance use disorders and inflammatory markers after adjustment for multiple covariates in a population-based study.

Glaus, Jennifer; Vandeleur, Caroline L; von Känel, Roland; Lasserre, Aurélie M; Strippoli, Marie-Pierre F; Gholam-Rezaee, Mehdi; Castelao, Enrique; Marques-Vidal, Pedro; Bovet, Pascal; Merikangas, Kathleen; Mooser, Vincent; Waeber, Gérard; Vollenweider, Peter; Aubry, Jean-Michel; Preisig, Martin (2014). Associations between mood, anxiety or substance use disorders and inflammatory markers after adjustment for multiple covariates in a population-based study. Journal of psychiatric research, 58, pp. 36-45. Elsevier 10.1016/j.jpsychires.2014.07.012

[img] Text
J_Psychiatr_Res_2014.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (232kB) | Request a copy

Inflammation is one possible mechanism underlying the associations between mental disorders and cardiovascular diseases (CVD). However, studies on mental disorders and inflammation have yielded inconsistent results and the majority did not adjust for potential confounding factors. We examined the associations of several pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) and high sensitive C-reactive protein (hsCRP) with lifetime and current mood, anxiety and substance use disorders (SUD), while adjusting for multiple covariates. The sample included 3719 subjects, randomly selected from the general population, who underwent thorough somatic and psychiatric evaluations. Psychiatric diagnoses were made with a semi-structured interview. Major depressive disorder was subtyped into "atypical", "melancholic", "combined atypical-melancholic" and "unspecified". Associations between inflammatory markers and psychiatric diagnoses were assessed using multiple linear and logistic regression models. Lifetime bipolar disorders and atypical depression were associated with increased levels of hsCRP, but not after multivariate adjustment. After multivariate adjustment, SUD remained associated with increased hsCRP levels in men (β = 0.13 (95% CI: 0.03,0.23)) but not in women. After multivariate adjustment, lifetime combined and unspecified depression were associated with decreased levels of IL-6 (β = -0.27 (-0.51,-0.02); β = -0.19 (-0.34,-0.05), respectively) and TNF-α (β = -0.16 (-0.30,-0.01); β = -0.10 (-0.19,-0.02), respectively), whereas current combined and unspecified depression were associated with decreased levels of hsCRP (β = -0.20 (-0.39,-0.02); β = -0.12 (-0.24,-0.01), respectively). Our data suggest that the significant associations between increased hsCRP levels and mood disorders are mainly attributable to the effects of comorbid disorders, medication as well as behavioral and physical CVRFs.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

von Känel, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-3956

Publisher:

Elsevier

Language:

English

Submitter:

Annette Barbara Kocher

Date Deposited:

26 Mar 2015 11:05

Last Modified:

26 Oct 2015 11:19

Publisher DOI:

10.1016/j.jpsychires.2014.07.012

PubMed ID:

25088287

Uncontrolled Keywords:

Anxiety disorders, C-Reactive protein, Depression subtypes, Mood disorders, Pro-inflammatory cytokines, Substance use disorders

BORIS DOI:

10.7892/boris.66471

URI:

https://boris.unibe.ch/id/eprint/66471

Actions (login required)

Edit item Edit item
Provide Feedback